Department of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University, 040 01 Košice, Slovakia.
Center of Clinical and Preclinical Research MEDIPARK, Faculty of Medicine, Pavol Jozef Šafárik University, 040 01 Košice, Slovakia.
Int J Mol Sci. 2023 Jun 19;24(12):10354. doi: 10.3390/ijms241210354.
There is no doubt that significant progress has been made in tumor therapy in the past decades. However, the discovery of new molecules with potential antitumor properties still remains one of the most significant challenges in the field of anticancer therapy. Nature, especially plants, is a rich source of phytochemicals with pleiotropic biological activities. Among a plethora of phytochemicals, chalcones, the bioprecursors of flavonoid and isoflavonoids synthesis in higher plants, have attracted attention due to the broad spectrum of biological activities with potential clinical applications. Regarding the antiproliferative and anticancer effects of chalcones, multiple mechanisms of action including cell cycle arrest, induction of different forms of cell death and modulation of various signaling pathways have been documented. This review summarizes current knowledge related to mechanisms of antiproliferative and anticancer effects of natural chalcones in different types of malignancies including breast cancers, cancers of the gastrointestinal tract, lung cancers, renal and bladder cancers, and melanoma.
毫无疑问，过去几十年肿瘤治疗取得了重大进展。然而，发现具有潜在抗肿瘤特性的新分子仍然是抗癌治疗领域最重大的挑战之一。大自然，尤其是植物，是具有多种生物活性的植物化学物质的丰富来源。在众多的植物化学物质中，查耳酮是高等植物类黄酮和异黄酮合成的生物前体，由于具有广泛的潜在临床应用的生物活性而引起了人们的关注。关于查耳酮的抗增殖和抗癌作用，已经记录了多种作用机制，包括细胞周期停滞、诱导不同形式的细胞死亡和调节各种信号通路。本文综述了天然查耳酮在不同类型恶性肿瘤（包括乳腺癌、胃肠道癌、肺癌、肾和膀胱癌和黑色素瘤）中的抗增殖和抗癌作用的机制的最新知识。
