Internal Medicine Department, Hospital of Marcianise, ASL Caserta, 81037 Caserta, Italy.
Internal Medicine Department, Hospital of Latina, ASL Latina, 04100 Latina, Italy.
Int J Mol Sci. 2023 Jun 20;24(12):10409. doi: 10.3390/ijms241210409.
The global prevalence of overweight and obesity has dramatically increased in the last few decades, with a significant socioeconomic burden. In this narrative review, we include clinical studies aiming to provide the necessary knowledge on the role of the gut microbiota in the development of diabetic pathology and glucose-metabolism-related disorders. In particular, the role of a certain microbial composition of the fermentative type seems to emerge without a specific link to the development in certain subjects of obesity and the chronic inflammation of the adipose tissues, which underlies the pathological development of all the diseases related to glucose metabolism and metabolic syndrome. The gut microbiota plays an important role in glucose tolerance. Conclusion. New knowledge and new information is presented on the development of individualized therapies for patients affected by all the conditions related to reduced glucose tolerance and insulin resistance.
在过去的几十年中，超重和肥胖的全球患病率显著增加，这给社会经济带来了巨大负担。在这篇叙述性综述中，我们纳入了旨在提供关于肠道微生物群在糖尿病病理和葡萄糖代谢相关疾病发展中作用的必要知识的临床研究。特别是，发酵型特定微生物组成的作用似乎出现了，而与肥胖和脂肪组织慢性炎症的发展并没有特定的联系，这是与葡萄糖代谢和代谢综合征相关的所有疾病的病理发展的基础。肠道微生物群在葡萄糖耐量中起着重要作用。结论。为受所有与葡萄糖耐量降低和胰岛素抵抗相关的疾病影响的患者提供了新的知识和信息，以制定个体化治疗方案。
