禁食鹅的环境温度与血浆酮体浓度

Ambient temperature and ketone body plasma concentration in fasting geese.

作者信息

Cherel Y, Robin J P, Nehlig A, Girard H, Lacombe A, Frain M, Le Maho Y

出版信息

Pflugers Arch. 1986 Jul;407(1):119-21. doi: 10.1007/BF00580732.

Abstract

The effect on ketonemia of alternate exposure to ambient temperatures (Ta) of 25 and 5 degrees C was investigated in fasting geese. Three experimental birds were compared to three controls continuously exposed to 25 degrees C Ta while fasting. During the first 9 days of fasting, when both groups were exposed to 25 degrees C, plasma concentration of beta-hydroxybutyrate (beta-OHB) increased similarly in both, from 0.10 +/- 0.02 to 6.62 +/- 0.71 mmol X L-1. It later plateaued at 8-9 mmol X L-1 in the control birds. When the experimental birds were exposed to 5 degrees C Ta between the 9th and 15th day of the fast, it increased further during the first 24 h but thereafter decreased of 57%, from 8.62 +/- 1.56 to 3.73 +/- 1.24 mmol X L-1. This decrease was reversed within the 6 days of return to 25 degrees C Ta. In both groups, plasma acetoacetate (AcAc) concentration remained very low during the fast: 51 +/- 1 mumol X L-1. This reversible cold-induced effect on ketonemia may be used for investigating the possible role of ketone bodies in protein sparing during fasting.

摘要

研究了禁食鹅交替暴露于25℃和5℃环境温度（Ta）对酮血症的影响。将三只实验鹅与三只在禁食期间持续暴露于25℃ Ta的对照鹅进行比较。在禁食的前9天，两组都暴露于25℃时，β-羟基丁酸（β-OHB）的血浆浓度在两组中相似地增加，从0.10±0.02增加到6.62±0.71 mmol·L-1。对照组鹅的β-OHB血浆浓度随后稳定在8 - 9 mmol·L-1。当实验鹅在禁食的第9天至第15天暴露于5℃ Ta时，β-OHB在最初24小时内进一步增加，但此后下降了57%，从8.62±1.56降至3.73±1.24 mmol·L-1。在恢复到25℃ Ta的6天内，这种下降得到了逆转。在两组中，禁食期间血浆乙酰乙酸（AcAc）浓度一直很低：51±1 μmol·L-1。这种由寒冷引起的对酮血症的可逆效应可用于研究酮体在禁食期间节省蛋白质方面可能发挥的作用。