Trofor Antigona Carmen, Cernomaz Andrei Tudor, Lotrean Lucia Maria, Crișan-Dabija Radu Adrian, Penalvo Jose L, Melinte Oana Elena, Popa Daniela Robu, Man Milena Adina
Discipline of Pneumology, III-rd Medical Department, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iași, Romania.
Discipline of Hygiene, Department of Community Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj, Romania.
J Pers Med. 2023 May 26;13(6):900. doi: 10.3390/jpm13060900.
We aimed to characterize the clinical features of moderate forms of COVID-19 requiring hospitalization and potentially identify predictors for unfavorable outcomes.
Pooled anonymized clinical data from 452 COVID-19 patients hospitalized in two regional Romanian respiratory disease centers during the Alpha and Delta variant outbreaks were included in the analysis.
Cough and shortness of breath were the most common clinical features; older patients exhibited more fatigue and dyspnea and fewer upper airway-related symptoms such as smell loss or sore throat. The presence of confusion, shortness of breath and age over 60 years were significantly associated with worse outcomes (odds ratios 5.73, 2.08 and 3.29, respectively).
The clinical picture on admission may have a prognostic role for moderate forms of COVID-19. Clear clinical definitions and developing adequate informational infrastructure allowing complex data sharing and analysis might be useful for fast research response should a similar outbreak occur in the future.
我们旨在描述需要住院治疗的中度新型冠状病毒肺炎（COVID-19）的临床特征，并有可能确定不良预后的预测因素。
分析纳入了罗马尼亚两个地区呼吸疾病中心在阿尔法和德尔塔变异株暴发期间住院的452例COVID-19患者的汇总匿名临床数据。
咳嗽和呼吸急促是最常见的临床特征；老年患者表现出更多疲劳和呼吸困难，而上呼吸道相关症状如嗅觉丧失或喉咙痛较少。意识模糊、呼吸急促和60岁以上与较差的预后显著相关（优势比分别为5.73、2.08和3.29）。
入院时的临床表现可能对中度COVID-19患者具有预后作用。明确的临床定义和建立足够的信息基础设施以允许复杂的数据共享和分析，可能有助于未来在类似疫情暴发时做出快速的研究反应。
