Kandasamy Geetha, Almeleebia Tahani
Department of Clinical Pharmacy, College of Pharmacy, King Khalid University (KKU), Abha 61421, Saudi Arabia.
J Pers Med. 2023 May 30;13(6):919. doi: 10.3390/jpm13060919.
Obstructive sleep apnea (OSA) is characterized by recurring episodes of pharyngeal collapse, which can partially or completely block airflow during sleep and cause cardiorespiratory and neurological imbalances. Therefore, the purpose of this study was to assess OSA and the relationship between AHI and polysomnographic characteristics in OSA patients. A prospective study was conducted at the Department of Pulmonology and Sleep Medicine for two years. All 216 participants underwent polysomnography, and 175 of them were reported to have OSA (AHI ≥ 5), while 41 of them did not (AHI < 5). ANOVA and Pearson's correlation coefficient test were performed. In terms of the study population's average AHI, Group 1 had 1.69 ± 1.34, mild OSA had 11.79 ± 3.55, moderate OSA had 22.12 ± 4.34, and severe OSA was found to have 59.16 ± 22.15 events/hour. The study group's average age was 53.77 ± 7.19 out of 175 OSA patients. According to AHI, the BMI for mild OSA was 31.66 ± 8.32 kg/m, for moderate OSA, it was 30.52 ± 3.99 kg/m, and for severe OSA, it was 34.35 ± 8.22 kg/m. The average number of oxygen desaturation events and snoring duration were 25.20 ± 18.63 and 24.61 ± 28.53 min, respectively. BMI ( = 0.249, < 0.001), average oxygen saturation ( = -0.387, < 0.000), oxygen desaturation ( = 0.661, < 0.000), snoring time ( = 0.231, < 0.002), and the number of snores ( = 0.383, < 0.001) were the polysomnographic variables that showed significant correlations with AHI in the study group. In this study, a substantial prevalence of obesity and a high OSA frequency were found in men. Our research showed that individuals with obstructive sleep apnea experience nocturnal desaturations. Polysomnography is the primary test for early detection of this treatable condition.
阻塞性睡眠呼吸暂停（OSA）的特征是咽部反复塌陷，这会在睡眠期间部分或完全阻断气流，并导致心肺和神经功能失衡。因此，本研究的目的是评估OSA以及OSA患者中呼吸暂停低通气指数（AHI）与多导睡眠图特征之间的关系。在肺病与睡眠医学科进行了一项为期两年的前瞻性研究。所有216名参与者均接受了多导睡眠图检查，其中175人被报告患有OSA（AHI≥5），而41人未患OSA（AHI＜5）。进行了方差分析和皮尔逊相关系数检验。就研究人群的平均AHI而言，第1组为1.69±1.34，轻度OSA为11.79±3.55，中度OSA为22.12±4.34，重度OSA为59.16±22.15次/小时。175名OSA患者的研究组平均年龄为53.77±7.19岁。根据AHI，轻度OSA的体重指数（BMI）为31.66±8.32kg/m，中度OSA为30.52±3.99kg/m，重度OSA为34.35±8.22kg/m。平均氧饱和度下降事件数和打鼾持续时间分别为25.20±18.63和24.61±28.53分钟。BMI（r = 0.249，P＜0.001）、平均氧饱和度（r = -0.387，P＜0.000）、氧饱和度下降（r = 0.661，P＜0.000）、打鼾时间（r = 0.231，P＜0.002）和打鼾次数（r = 0.383，P＜0.001）是研究组中与AHI显示出显著相关性的多导睡眠图变量。在本研究中，发现男性中肥胖的患病率很高且OSA频率也很高。我们的研究表明，阻塞性睡眠呼吸暂停患者会出现夜间氧饱和度下降。多导睡眠图是早期发现这种可治疗疾病的主要检查方法。
