烟酸、异柠檬酸或N-乙酰半胱氨酸对小鼠阿霉素心脏毒性的预防作用。一项形态学研究。

Prevention of adriamycin cardiotoxicity by niacin, isocitrate or N-acetyl-cysteine in mice. A morphological study.

作者信息

Schmitt-Gräff A, Scheulen M E

出版信息

Pathol Res Pract. 1986 May;181(2):168-74. doi: 10.1016/S0344-0338(86)80006-1.

Abstract

Adriamycin is known to produce treatment limiting cardiotoxicity. We studied the effect of niacin, isocitrate, and N-acetyl-cysteine on cumulative adriamycin-induced cardiotoxicity in NMRI mice. Pathologic grading of the hearts indicated a significant reduction in myocardial injury. In addition, according to median survival and weight changes there was a significant decrease in toxicity. As demonstrated in Ehrlich ascites tumor, coadministration of N-acetyl-cysteine may interfere with the antitumor activity of adriamycin. In contrast, niacin and isocitrate did not show significant inhibition of antineoplastic activity. Our experiments suggest a promising role of niacin and isocitrate as potential cardioprotectors in the course of chemotherapy with adriamycin.

摘要

已知阿霉素会产生限制治疗的心脏毒性。我们研究了烟酸、异柠檬酸和N-乙酰半胱氨酸对阿霉素诱导的NMRI小鼠累积心脏毒性的影响。心脏的病理分级表明心肌损伤显著减轻。此外，根据中位生存期和体重变化，毒性也显著降低。正如在艾氏腹水瘤实验中所证明的，同时给予N-乙酰半胱氨酸可能会干扰阿霉素的抗肿瘤活性。相比之下，烟酸和异柠檬酸并未显示出对抗肿瘤活性的显著抑制作用。我们的实验表明，烟酸和异柠檬酸作为阿霉素化疗过程中的潜在心脏保护剂具有广阔前景。