Adriamycin-induced cardiac damage in the mouse: a small-animal model of cardiotoxicity.
作者信息
Rosenoff S H, Olson H M, Young D M, Bostick F, Young R C
出版信息
J Natl Cancer Inst. 1975 Jul;55(1):191-4. doi: 10.1093/jnci/55.1.191.
PMID:1159813
Abstract
After one dose of adriamycin, a subacute cardiomyopathy was observed in the mouse by both light and electron microscopy. The microscopic alterations were characterized by single-cell necrosis and mitochondrial degeneration. These lesions were similar to those seen in man and shortly preceded fatal toxicity.
摘要
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