Efremenko Elena, Senko Olga, Stepanov Nikolay, Aslanli Aysel, Maslova Olga, Lyagin Ilya
Faculty of Chemistry, Lomonosov Moscow State University, Lenin Hills 1/3, 119991 Moscow, Russia.
Microorganisms. 2023 May 25;11(6):1395. doi: 10.3390/microorganisms11061395.
Quorum sensing (QS) of various microorganisms (bacteria, fungi, microalgae) today attracts the attention of researchers mainly from the point of view of clarifying the biochemical basics of this general biological phenomenon, establishing chemical compounds that regulate it, and studying the mechanisms of its realization. Such information is primarily aimed at its use in solving environmental problems and the development of effective antimicrobial agents. This review is oriented on other aspects of the application of such knowledge; in particular, it discusses the role of QS in the elaboration of various prospective biocatalytic systems for different biotechnological processes carried out under aerobic and anaerobic conditions (synthesis of enzymes, polysaccharides, organic acids, etc.). Particular attention is paid to the biotechnological aspects of QS application and the use of biocatalysts, which have a heterogeneous microbial composition. The priorities of how to trigger a quorum response in immobilized cells to maintain their long-term productive and stable metabolic functioning are also discussed. There are several approaches that can be realized: increase in cell concentration, introduction of inductors for synthesis of QS-molecules, addition of QS-molecules, and provoking competition between the participants of heterogeneous biocatalysts, etc.).
如今，各种微生物（细菌、真菌、微藻）的群体感应（QS）吸引了研究人员的关注，主要是从阐明这一普遍生物学现象的生化基础、确定调节它的化合物以及研究其实现机制的角度。此类信息主要旨在用于解决环境问题和开发有效的抗菌剂。本综述关注的是此类知识应用的其他方面；特别是，它讨论了群体感应在为需氧和厌氧条件下进行的不同生物技术过程（酶、多糖、有机酸等的合成）设计各种潜在生物催化系统中的作用。特别关注群体感应应用的生物技术方面以及具有异质微生物组成的生物催化剂的使用。还讨论了如何在固定化细胞中引发群体感应反应以维持其长期高效和稳定代谢功能的优先事项。有几种方法可以实现：增加细胞浓度、引入用于合成群体感应分子的诱导剂、添加群体感应分子以及引发异质生物催化剂参与者之间的竞争等。
