Efremenko Elena, Stepanov Nikolay, Senko Olga, Maslova Olga, Lyagin Ilya, Domnin Maksim, Aslanli Aysel
Faculty of Chemistry, Lomonosov Moscow State University, Lenin Hills 1/3, Moscow 119991, Russia.
Microorganisms. 2024 Aug 12;12(8):1650. doi: 10.3390/microorganisms12081650.
The unresolved challenges in the development of highly efficient, stable and controlled synthetic microbial consortia, as well as the use of natural consortia, are very attractive for science and technology. However, the consortia management should be done with the knowledge of how not only to accelerate but also stop the action of such "little pots". Moreover, there are a lot of microbial consortia, the activity of which should be suppressively controlled. The processes, catalyzed by various microorganisms being in complex consortia which should be slowed down or completely cancelled, are typical for the environment (biocorrosion, landfill gas accumulation, biodegradation of building materials, water sources deterioration etc.), industry (food and biotechnological production), medical practice (vaginitis, cystitis, intestinal dysbiosis, etc.). The search for ways to suppress the functioning of heterogeneous consortia in each of these areas is relevant. The purpose of this review is to summarize the general trends in these studies regarding the targets and new means of influence used. The analysis of the features of the applied approaches to solving the main problem confirms the possibility of obtaining a combined effect, as well as selective influence on individual components of the consortia. Of particular interest is the role of viruses in suppressing the functioning of microbial consortia of different compositions.
开发高效、稳定且可控的合成微生物群落以及利用天然群落过程中尚未解决的挑战，对科学技术极具吸引力。然而，在管理群落时，不仅要知道如何加速，还要知道如何停止这些“小罐子”的作用。此外，有许多微生物群落的活性需要进行抑制性控制。由处于复杂群落中的各种微生物催化的过程，如生物腐蚀、垃圾填埋气积聚、建筑材料生物降解、水源恶化等环境问题，食品和生物技术生产等工业问题，阴道炎、膀胱炎、肠道菌群失调等医学问题，都需要减缓或完全消除。在这些领域中寻找抑制异质群落功能的方法具有重要意义。本综述的目的是总结这些研究在目标和新的影响手段方面的总体趋势。对解决主要问题所采用方法的特点进行分析，证实了获得联合效应以及对群落中各个成分进行选择性影响的可能性。病毒在抑制不同组成的微生物群落功能中所起的作用尤其令人感兴趣。
