Doulberis Michael, Kountouras Jannis, Stadler Thomas, Meerwein Christian, Polyzos Stergios A, Kulaksiz Hasan, Chapman Michael H, Rogler Gerhard, Riva Daniele, Linas Ioannis, Kavaliotis John, Kazakos Evangelos, Mouratidou Maria, Liatsos Christos, Papaefthymiou Apostolis
Gastroklinik, Private Gastroenterological Practice, 8810 Horgen, Switzerland.
Department of Gastroenterology, University Hospital Zurich, 8091 Zurich, Switzerland.
Microorganisms. 2023 Jun 14;11(6):1581. doi: 10.3390/microorganisms11061581.
() has definite or possible associations with multiple local and distant manifestations. has been isolated from multiple sites throughout the body, including the nose. Clinical non-randomized studies with report discrepant data regarding the association between infection and nasal polyps. The aim of this first systematic review and meta-analysis was the assessment of the strength of the association between infection and incidence of nasal polyps.
We performed an electronic search in the three major medical databases, namely PubMed, EMBASE and Cochrane, to extract and analyze data as per PRISMA guidelines.
Out of 57 articles, 12 studies were graded as good quality for analysis. Male-to-female ratio was 2:1, and age ranged between 17-78 years. The cumulative pooled rate of infection in the nasal polyp group was 32.3% (controls 17.8%). The comparison between the two groups revealed a more significant incidence of infection among the nasal polyp group (OR 4.12), though with high heterogeneity I = 66%. Subgroup analysis demonstrated that in European studies, the prevalence of infection among the nasal polyp group was significantly higher than in controls, yielding null heterogeneity. Subgroup analysis based on immunohistochemistry resulted in null heterogeneity with preserving a statistically significant difference in infection prevalence between the groups.
The present study revealed a positive association between infection and nasal polyps.
（某病原体）与多种局部和远处表现存在明确或可能的关联。已在包括鼻子在内的全身多个部位分离出该病原体。关于该病原体感染与鼻息肉之间的关联，临床非随机研究报告的数据存在差异。这项首次系统评价和荟萃分析的目的是评估该病原体感染与鼻息肉发病率之间关联的强度。
我们在三个主要医学数据库，即PubMed、EMBASE和Cochrane中进行了电子检索，以按照PRISMA指南提取和分析数据。
在57篇文章中，有12项研究被评为质量良好可用于分析。男女比例为2:1，年龄在17 - 78岁之间。鼻息肉组中该病原体感染的累积合并率为32.3%（对照组为17.8%）。两组之间的比较显示，鼻息肉组中该病原体感染的发生率更高（比值比4.12），尽管异质性较高（I = 66%）。亚组分析表明，在欧洲的研究中，鼻息肉组中该病原体感染的患病率显著高于对照组，异质性为零。基于免疫组织化学的亚组分析异质性为零，两组之间该病原体感染患病率仍存在统计学显著差异。
本研究揭示了该病原体感染与鼻息肉之间存在正相关。
