Sharma Satish, Mohler James, Mahajan Supriya D, Schwartz Stanley A, Bruggemann Liana, Aalinkeel Ravikumar
Department of Urology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14260, USA.
Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.
Microorganisms. 2023 Jun 19;11(6):1614. doi: 10.3390/microorganisms11061614.
Biofilm is complex and consists of bacterial colonies that reside in an exopolysaccharide matrix that attaches to foreign surfaces in a living organism. Biofilm frequently leads to nosocomial, chronic infections in clinical settings. Since the bacteria in the biofilm have developed antibiotic resistance, using antibiotics alone to treat infections brought on by biofilm is ineffective. This review provides a succinct summary of the theories behind the composition of, formation of, and drug-resistant infections attributed to biofilm and cutting-edge curative approaches to counteract and treat biofilm. The high frequency of medical device-induced infections due to biofilm warrants the application of innovative technologies to manage the complexities presented by biofilm.
生物膜很复杂，由存在于胞外多糖基质中的细菌菌落组成，该基质附着在生物体内的外来表面上。在临床环境中，生物膜经常导致医院获得性慢性感染。由于生物膜中的细菌已产生抗生素耐药性，仅使用抗生素治疗由生物膜引起的感染是无效的。这篇综述简要总结了生物膜的组成、形成以及耐药感染背后的理论，以及对抗和治疗生物膜的前沿治疗方法。由生物膜引起的医疗器械相关感染的高发生率，使得应用创新技术来应对生物膜带来的复杂性成为必要。
