Phanerosides A-X，苯丙素酯类蔗糖衍生物来自黄藤属植物。
Phanerosides A-X, Phenylpropanoid Esters of Sucrose from the Rattans of Benth.
机构信息
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China.
出版信息
Molecules. 2023 Jun 14;28(12):4767. doi: 10.3390/molecules28124767.
Twenty-four new phenylpropanoid esters of sucrose, phanerosides A-X (-), were isolated from an EtOH extract of the rattans of Benth. (Fabaceae). Their structures were elucidated on the basis of comprehensive spectroscopic data analysis. A wide range of structural analogues were presented due to the different numbers and positions of acetyl substituents and the structures of phenylpropanoid moieties. Phenylpropanoid esters of sucrose were isolated from the Fabaceae family for the first time. Biologically, the inhibitory effects of compounds and on NO production in LPS-induced BV-2 microglial cells were better than that of the positive control, with IC values of 6.7 and 5.2 μM, respectively. The antioxidant activity assay showed that compounds , , , and displayed moderate DPPH radical scavenging activity, with IC values ranging from 34.9 to 43.9 μM.
从 Benth.（豆科）藤本植物的乙醇提取物中分离得到 24 种新的蔗糖苯丙素酯，phanerosides A-X(-)。基于综合光谱数据分析，阐明了它们的结构。由于乙酰基取代基的数量和位置以及苯丙素部分的结构不同，呈现出广泛的结构类似物。首次从豆科植物中分离到蔗糖苯丙素酯。生物活性方面，化合物和对 LPS 诱导的 BV-2 小胶质细胞中 NO 生成的抑制作用优于阳性对照，IC 值分别为 6.7 和 5.2 μM。抗氧化活性测定表明，化合物、、、和对 DPPH 自由基具有中等的清除活性，IC 值范围为 34.9 至 43.9 μM。
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