栀子果实中的环烯醚萜苷和木脂素
Iridoid glycosides and lignans from the fruits of Gardenia jasminoides Eills.
机构信息
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, PR China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, PR China.
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, PR China; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou, 450046, PR China; Co-Construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of PR China, Zhengzhou, 450046, PR China.
出版信息
Phytochemistry. 2021 Oct;190:112893. doi: 10.1016/j.phytochem.2021.112893. Epub 2021 Jul 28.
Four previously undescribed iridoid glycosides, including two bis-iridoid glycosides, and three undescribed lignans, together with 16 known analogues, were isolated from the fruits of Gardenia jasminoides Eills. Their structures were elucidated on basis of spectroscopic methods, and the absolute configurations of three of the unknown compounds were determined by interpretation of their electronic circular dichroic (ECD) and [α] [Formula: see text] data. The α-glucosidase inhibitory effects of the isolated compounds were evaluated and all the compounds exhibited slightly inhibitory activity with the values of IC greater than 50 μM.
从栀子果实中分离得到 4 个以前未描述过的环烯醚萜苷类化合物，包括 2 个双环烯醚萜苷类化合物，以及 3 个未描述过的木脂素类化合物，同时还分离得到 16 个已知类似物。基于光谱方法阐明了它们的结构，通过对 3 个未知化合物的电子圆二色性（ECD）和[α] [Formula: see text]数据的解释，确定了它们的绝对构型。评价了分离得到的化合物对 α-葡萄糖苷酶的抑制作用，所有化合物均表现出轻微的抑制活性，IC 值大于 50 μM。
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