Nutrition & Health Innovation Research Institute, School of Medical and Health Science, Edith Cowan University, Joondalup, WA 6027, Australia.
Medical School, The University of Western Australia, Nedlands, WA 6009, Australia.
Nutrients. 2023 Jun 8;15(12):2669. doi: 10.3390/nu15122669.
We aimed to compare the dietary intakes of Australian patients with non-alcoholic fatty liver disease (NAFLD) to general Australian population intake data and determine whether the intake of any nutrient or food group was able to predict the degree of steatosis. Dietary data from fifty adult patients with NAFLD were compared to intake data from the Australian Health Survey for energy, macronutrients, fat sub-types, alcohol, iron, folate, sugar, fibre, sodium and caffeine. Linear regression models adjusting for potential confounders (age, sex, physical activity and body mass index) were used to examine predictive relationships between hepatic steatosis (quantified via magnetic resonance spectroscopy) and dietary components. The mean percentage differences between NAFLD and Australian usual intakes were significant for energy, protein, total fat, saturated fat, monounsaturated and polyunsaturated fats (all < 0.001). The contribution of fat and protein to total energy intake was significantly higher in the NAFLD cohort ( < 0.05). No individual nutrients or food groups were strongly related to hepatic fat in the adjusted models. Higher overall consumption appears to be a major feature of dietary intake in NAFLD when compared to the general population. A whole-diet approach to NAFLD treatment and prevention is likely to be more effective than focusing on single food components.
我们旨在比较澳大利亚非酒精性脂肪性肝病 (NAFLD) 患者的饮食摄入与澳大利亚一般人群的摄入数据，并确定任何营养素或食物组的摄入是否能够预测脂肪变性的程度。将 50 名成年 NAFLD 患者的饮食数据与澳大利亚健康调查的能量、宏量营养素、脂肪亚类、酒精、铁、叶酸、糖、纤维、钠和咖啡因摄入数据进行比较。使用线性回归模型调整潜在混杂因素（年龄、性别、身体活动和体重指数），以检查肝脂肪变性（通过磁共振光谱法定量）与饮食成分之间的预测关系。NAFLD 与澳大利亚通常摄入量之间的平均百分比差异在能量、蛋白质、总脂肪、饱和脂肪、单不饱和脂肪和多不饱和脂肪方面均具有统计学意义（均 < 0.001）。NAFLD 组的脂肪和蛋白质在总能量摄入中的贡献率明显更高（< 0.05）。在调整后的模型中，没有任何单一营养素或食物组与肝脂肪有很强的相关性。与一般人群相比，NAFLD 患者的整体饮食摄入量似乎更高。与关注单一食物成分相比，采用全饮食方法治疗和预防 NAFLD 可能更有效。
