Key Laboratory of Endocrinology of National Health Commission, Diabetes Research Center of Chinese Academy of Medical Sciences, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Xin-Hua Xiao, No. 1 Shuaifuyuan, Wangfujing Street, Dongcheng District, Beijing 100730, China.
Department of Medical Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Nutrients. 2023 Jun 19;15(12):2793. doi: 10.3390/nu15122793.
Maternal exercise benefits offspring's metabolic health with long-term repercussions. Here, we systematically reviewed the effects of maternal exercise on offspring obesity outcomes in adulthood. The primary outcome is body weight. The secondary outcomes are glucose and lipid profiles. Two independent authors performed a search in the databases PubMed, EMBASE, and Web of Science. A total of nine studies with 17 different cohorts consisting of 369 animals (two species) were included. Study quality was assessed using the SYRCLE risk of bias. The PRISMA statement was used to report this systematic review. The results showed that maternal exercise contributes to improved glucose tolerance, reduced insulin concentration, and lower total cholesterol and low density lipoprotein levels in adult offspring in mice, which are independent of maternal body weight and offspring dietary condition. Additionally, in rats, maternal exercise leads to a higher body weight in adult offspring, which might be attributed to the high-fat diet of offspring after weaning. These findings further support the metabolic beneficial role of maternal exercise on offspring in adulthood, although the issue of translating the results to the human population is still yet to be addressed.
母体运动有益于后代的代谢健康，并产生长期影响。在这里，我们系统地综述了母体运动对成年后代肥胖结局的影响。主要结局是体重。次要结局是葡萄糖和脂质谱。两位独立的作者在 PubMed、EMBASE 和 Web of Science 数据库中进行了检索。共有 9 项研究，包含 17 个不同的队列，涉及 369 只动物（两种物种）被纳入研究。使用 SYRCLE 偏倚风险评估工具评估了研究质量。本系统综述按照 PRISMA 声明进行报告。结果表明，母体运动有助于改善成年后代的葡萄糖耐量，降低胰岛素浓度，降低总胆固醇和低密度脂蛋白水平，这与母体体重和后代饮食条件无关。此外，在大鼠中，母体运动导致成年后代体重增加，这可能归因于断奶后后代的高脂肪饮食。这些发现进一步支持了母体运动对成年后代的代谢有益作用，尽管将这些结果转化为人类群体的问题仍有待解决。
