Majee Suman, Sarav Mansi, Banik Bimal Krishna, Ray Devalina
Amity Institute of Click Chemistry Research and Studies, Amity University, Sector 125, Noida 201313, Uttar Pradesh, India.
Amity Institute of Biotechnology, Amity University, Sector 125, Noida 201313, Uttar Pradesh, India.
Pharmaceuticals (Basel). 2023 Jun 13;16(6):873. doi: 10.3390/ph16060873.
-heterocyclic scaffolds represent a privileged architecture in the process of drug design and development. It has widespread occurrence in synthetic and natural products, either those that are established or progressing as potent drug candidates. Additionally, numerous novel -heterocyclic analogues with remarkable physiological significance and extended pharmaceutical applications are escalating progressively. Hence, the classical synthetic protocols need to be improvised according to modern requirements for efficient and eco-friendly approaches. Numerous methodologies and technologies emerged to address the green and sustainable production of various pharmaceutically and medicinally important -heterocyclic compounds in last few years. In this context, the current review unveils greener alternatives for direct access to categorically differentiated -heterocyclic derivatives and its application in the establishment of biologically active potent molecules for drug design. The green and sustainable methods accentuated in this review includes microwave-assisted reactions, solvent-free approaches, heterogeneous catalysis, ultrasound reactions, and biocatalysis.
杂环骨架在药物设计与开发过程中代表着一种优势结构。它广泛存在于合成产物和天然产物中，无论是已确立的还是正在作为有潜力的候选药物发展的那些产物。此外，众多具有显著生理意义和广泛药物应用的新型杂环类似物正在逐渐增加。因此，经典的合成方案需要根据现代对高效和环保方法的要求进行改进。在过去几年中，出现了许多方法和技术来实现各种药学和医学上重要的杂环化合物的绿色可持续生产。在此背景下，当前的综述揭示了更环保的替代方法，以直接获得分类不同的杂环衍生物及其在建立用于药物设计的生物活性强效分子中的应用。本综述中强调的绿色可持续方法包括微波辅助反应、无溶剂方法、多相催化、超声反应和生物催化。
