Omidian Hossein, Mfoafo Kwadwo
College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Pharmaceutics. 2023 May 24;15(6):1583. doi: 10.3390/pharmaceutics15061583.
The utilization of nanotechnology has brought about notable advancements in the field of pediatric medicine, providing novel approaches for drug delivery, disease diagnosis, and tissue engineering. Nanotechnology involves the manipulation of materials at the nanoscale, resulting in improved drug effectiveness and decreased toxicity. Numerous nanosystems, including nanoparticles, nanocapsules, and nanotubes, have been explored for their therapeutic potential in addressing pediatric diseases such as HIV, leukemia, and neuroblastoma. Nanotechnology has also shown promise in enhancing disease diagnosis accuracy, drug availability, and overcoming the blood-brain barrier obstacle in treating medulloblastoma. It is important to acknowledge that while nanotechnology offers significant opportunities, there are inherent risks and limitations associated with the use of nanoparticles. This review provides a comprehensive summary of the existing literature on nanotechnology in pediatric medicine, highlighting its potential to revolutionize pediatric healthcare while also recognizing the challenges and limitations that need to be addressed.
纳米技术的应用在儿科学领域带来了显著进展,为药物递送、疾病诊断和组织工程提供了新方法。纳米技术涉及在纳米尺度上对材料进行操控,从而提高药物疗效并降低毒性。人们已经探索了众多纳米系统,包括纳米颗粒、纳米胶囊和纳米管,以研究它们在治疗儿科疾病(如艾滋病毒、白血病和神经母细胞瘤)方面的治疗潜力。纳米技术在提高疾病诊断准确性、药物可及性以及克服髓母细胞瘤治疗中的血脑屏障障碍方面也显示出前景。必须认识到,虽然纳米技术提供了重大机遇,但使用纳米颗粒存在固有风险和局限性。本综述全面总结了儿科学中有关纳米技术的现有文献,强调了其变革儿科医疗保健的潜力,同时也认识到需要应对的挑战和局限性。