Department of Chemistry, College of Science, Salahaddin University-Erbil, Erbil, Iraq.
Department of Pharmaceutics, Faculty of Pharmacy, Tishk International University, Erbil, Iraq.
J Cell Physiol. 2024 Nov;239(11):e31236. doi: 10.1002/jcp.31236. Epub 2024 Mar 7.
Gene therapy is a revolutionary technology in healthcare that provides novel therapeutic options and has immense potential in addressing genetic illnesses, malignancies, and viral infections. Nevertheless, other obstacles still need to be addressed regarding safety, ethical implications, and technological enhancement. Nanotechnology and gene therapy fields have shown significant promise in transforming medical treatments by improving accuracy, effectiveness, and personalization. This review assesses the possible uses of gene therapy, its obstacles, and future research areas, specifically emphasizing the creative combination of gene therapy and nanotechnology. Nanotechnology is essential for gene delivery as it allows for the development of nano-scale carriers, such as carbon quantum dots (CQDs), which may effectively transport therapeutic genes into specific cells. CQDs exhibit distinctive physicochemical characteristics such as small size, excellent stability, and minimal toxicity, which render them highly favorable for gene therapy applications. The objective of this study is to review and describe the current advancements in the utilization of CQDs for gene delivery. Additionally, it intends to assess existing research, explore novel applications, and identify future opportunities and obstacles. This study offers a thorough summary of the current state and future possibilities of using CQDs for gene delivery. Combining recent research findings highlights the potential of CQDs to revolutionize gene therapy and its delivery methods.
基因治疗是医疗保健领域的一项革命性技术，提供了新的治疗选择，在治疗遗传疾病、恶性肿瘤和病毒感染方面具有巨大潜力。然而，在安全性、伦理影响和技术增强方面仍有其他障碍需要解决。纳米技术和基因治疗领域在通过提高准确性、有效性和个性化来改变医疗方面显示出巨大的潜力。本综述评估了基因治疗的可能用途、其障碍和未来的研究领域，特别是强调基因治疗与纳米技术的创造性结合。纳米技术对于基因传递至关重要，因为它允许开发纳米级载体，例如碳量子点 (CQD)，其可以有效地将治疗基因递送到特定细胞中。CQD 具有独特的物理化学特性，例如小尺寸、优异的稳定性和最小的毒性，这使其非常适合基因治疗应用。本研究的目的是综述和描述 CQD 用于基因传递的最新进展。此外，它旨在评估现有研究、探索新的应用，并确定未来的机会和障碍。本研究全面总结了使用 CQD 进行基因传递的现状和未来可能性。结合最近的研究结果，突出了 CQD 有潜力彻底改变基因治疗及其传递方法。
