Zhong Xuemei, Wang Guoqing, Li Fu, Fang Sixian, Zhou Siai, Ishiwata Akihiro, Tonevitsky Alexander G, Shkurnikov Maxim, Cai Hui, Ding Feiqing
School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus, Sun Yat-sen University, Shenzhen 518107, China.
Medical College, Shaoguan University, Shaoguan 512026, China.
Pharmaceutics. 2023 May 29;15(6):1615. doi: 10.3390/pharmaceutics15061615.
β-glucan, one of the homopolysaccharides composed of D-glucose, exists widely in cereals and microorganisms and possesses various biological activities, including anti-inflammatory, antioxidant, and anti-tumor properties. More recently, there has been mounting proof that β-glucan functions as a physiologically active "biological response modulator (BRM)", promoting dendritic cell maturation, cytokine secretion, and regulating adaptive immune responses-all of which are directly connected with β-glucan-regulated glucan receptors. This review focuses on the sources, structures, immune regulation, and receptor recognition mechanisms of β-glucan.
β-葡聚糖是由D-葡萄糖组成的同多糖之一，广泛存在于谷物和微生物中，并具有多种生物活性，包括抗炎、抗氧化和抗肿瘤特性。最近，越来越多的证据表明，β-葡聚糖作为一种生理活性的“生物反应调节剂（BRM）”发挥作用，促进树突状细胞成熟、细胞因子分泌以及调节适应性免疫反应——所有这些都与β-葡聚糖调节的葡聚糖受体直接相关。本文综述了β-葡聚糖的来源、结构、免疫调节和受体识别机制。
