, a well-known medicinal mushroom, has garnered attention for its broad therapeutic properties, particularly its potent antimicrobial activities. This review focuses on the mechanisms of action and bioactive compounds responsible for the ability of to inhibit various pathogenic microorganisms. The polysaccharides, triterpenoids, proteins, and phenolic compounds in exhibit strong antimicrobial effects by targeting bacterial cell walls, disrupting membrane integrity, and inhibiting key microbial enzymes. These compounds are effective against a wide range of bacteria, including , , , and various fungi. Triterpenoids, specifically, have demonstrated efficacy in modulating immune responses, further enhancing the body's defense mechanisms against infections. Furthermore, the role of in preventing biofilm formation and combating antibiotic-resistant strains highlights its potential as a natural antimicrobial agent. While and studies strongly support the antimicrobial properties of , future resety -50arch should focus on large-scale clinical trials to confirm its efficacy and explore its synergistic effects with conventional antibiotics. Establishing standardized dosages and exploring the molecular pathways of its antimicrobial actions will be key to incorporating into clinical practice for infection control.