Karunarathna Samantha C, Patabendige Nimesha M, Hapuarachchi Kalani K, Promputtha Itthayakorn
Center for Yunnan Plateau Biological Resources Protection and Utilization, College of Biology and Food Engineering, Qujing Normal University, Qujing, Yunnan, China.
School of Medical, Molecular and Forensic Sciences, Murdoch University, Murdoch, WA, Australia.
Front Cell Infect Microbiol. 2025 Jul 18;15:1535246. doi: 10.3389/fcimb.2025.1535246. eCollection 2025.
, a well-known medicinal mushroom, has garnered attention for its broad therapeutic properties, particularly its potent antimicrobial activities. This review focuses on the mechanisms of action and bioactive compounds responsible for the ability of to inhibit various pathogenic microorganisms. The polysaccharides, triterpenoids, proteins, and phenolic compounds in exhibit strong antimicrobial effects by targeting bacterial cell walls, disrupting membrane integrity, and inhibiting key microbial enzymes. These compounds are effective against a wide range of bacteria, including , , , and various fungi. Triterpenoids, specifically, have demonstrated efficacy in modulating immune responses, further enhancing the body's defense mechanisms against infections. Furthermore, the role of in preventing biofilm formation and combating antibiotic-resistant strains highlights its potential as a natural antimicrobial agent. While and studies strongly support the antimicrobial properties of , future resety -50arch should focus on large-scale clinical trials to confirm its efficacy and explore its synergistic effects with conventional antibiotics. Establishing standardized dosages and exploring the molecular pathways of its antimicrobial actions will be key to incorporating into clinical practice for infection control.
[某种著名的药用蘑菇]因其广泛的治疗特性，尤其是强大的抗菌活性而备受关注。本综述聚焦于[该蘑菇]抑制各种致病微生物能力的作用机制和生物活性化合物。[该蘑菇]中的多糖、三萜类化合物、蛋白质和酚类化合物通过靶向细菌细胞壁、破坏膜完整性和抑制关键微生物酶来展现强大的抗菌作用。这些化合物对多种细菌有效，包括[列举的细菌种类]以及各种真菌。特别是三萜类化合物已证明在调节免疫反应方面有效，进一步增强了机体对感染的防御机制。此外，[该蘑菇]在预防生物膜形成和对抗抗生素耐药菌株方面的作用凸显了其作为天然抗菌剂的潜力。虽然[相关研究]有力地支持了[该蘑菇]的抗菌特性，但未来的研究应侧重于大规模临床试验，以确认其疗效并探索其与传统抗生素的协同作用。确定标准化剂量并探索其抗菌作用的分子途径将是将[该蘑菇]纳入感染控制临床实践的关键。
需注意，原文中存在一些拼写错误，如“resety -[此处错误较多无法准确还原，推测可能是reset相关错误]50arch”，以上译文是尽量在理解原文大意基础上进行的翻译。
