海人酸会耗尽大鼠视网膜中的苯乙醇胺 - N - 甲基转移酶活性。
Kainic acid depletes retinal phenylethanolamine-N-methyltransferase activity of rats.
作者信息
Cohen J
出版信息
Proc Soc Exp Biol Med. 1986 Sep;182(4):576-9. doi: 10.3181/00379727-182-4-rc5.
PMID:3737617
Abstract
Kainic acid, an excitotoxic agent to the retina as well as to neuronal cell bodies in the brain, was administered intraocularly to rats in order to study the sensitivity of phenylethanolamine-N-Methyltransferase (PNMT) containing amacrine cells to this agent. Results show that these cells are very sensitive to the toxic effects of kainate. A dose of 5 nmoles caused a significant reduction in retinal PNMT activity. Higher doses further depleted enzyme activity.
摘要
海人酸是一种对视网膜以及大脑神经元细胞体具有兴奋毒性的物质，为了研究含有苯乙醇胺-N-甲基转移酶（PNMT）的无长突细胞对这种物质的敏感性，将其眼内注射给大鼠。结果显示，这些细胞对海人酸盐的毒性作用非常敏感。5纳摩尔的剂量会导致视网膜PNMT活性显著降低。更高的剂量会进一步耗尽酶活性。
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