Yang Ying, Huang Lisu
Department of Infectious Diseases, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China.
Vaccines (Basel). 2023 Jun 19;11(6):1114. doi: 10.3390/vaccines11061114.
Nowadays, people all over the world have been receiving different types of coronavirus disease 2019 (COVID-19) vaccines. While their effectiveness has been well recognized, various post-vaccination disorders are not fully understood. In this review, we discuss neurological disorders related to vascular, immune, infectious, and functional factors following COVID-19 vaccination, and attempt to provide neuroscientists, psychiatrists, and vaccination staff with a reference for the diagnosis and treatment of these diseases. These disorders may present as a recurrence of previous neurological disorders or new-onset diseases. Their incidence rate, host and vaccine characteristics, clinical manifestations, treatment, and prognosis differ significantly. The pathogenesis of many of them remains unclear, and further studies are needed to provide more evidence. The incidence rate of severe neurological disorders is relatively low, most of which are reversible or treatable. Therefore, the benefits of vaccination outweigh the risk of COVID-19 infection, especially among fragile populations.
如今,全世界的人们都在接种不同类型的2019冠状病毒病(COVID-19)疫苗。虽然其有效性已得到充分认可,但各种接种后疾病尚未完全明了。在这篇综述中,我们讨论了COVID-19疫苗接种后与血管、免疫、感染和功能因素相关的神经系统疾病,并试图为神经科学家、精神科医生和疫苗接种人员提供这些疾病诊断和治疗的参考。这些疾病可能表现为既往神经系统疾病的复发或新发疾病。它们的发病率、宿主和疫苗特性、临床表现、治疗及预后差异显著。其中许多疾病的发病机制仍不清楚,需要进一步研究以提供更多证据。严重神经系统疾病的发病率相对较低,大多数是可逆的或可治疗的。因此,接种疫苗的益处大于感染COVID-19的风险,尤其是在脆弱人群中。