Albakri Khaled, Khaity Abdulrhman, Atwan Hany, Saleh Othman, Al-Hajali Momen, Cadri Shirin, Diab Rehab Adel, Albazee Ebraheem, Negida Ahmed
Department of Surgery, Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan.
Medical Research Group of Egypt (MRGE), Cairo 11511, Egypt.
Vaccines (Basel). 2023 Jan 20;11(2):236. doi: 10.3390/vaccines11020236.
Once the COVID-19 pandemic was declared, the world was waiting for the clue that would be able to cut down the progression of the disease. Vaccines play a crucial role in reducing the disease and saving many people worldwide. However, there are several side effects of these vaccines, like pain, fatigue, fever, and neurological defects like Bell's palsy. In this systematic review, we presented evidence about the occurrence of Bell's palsy followed by COVID-19 vaccination.
We searched PubMed, SCOPUS, EBSCO, and Web of Science (WOS) from inception till October 2022. The quality assessment was conducted using the Joanna Briggs Institute, National Institute of Health, and Newcastle-Ottawa. The analysis was conducted on SPSS.
Thirty-five records were involved in our study. The results of our cases revealed that most of the patients (62.8%) experienced unilateral facial paralysis. Also, the majority of the cases were reported after the first dose, and most cases were after Pfizer, AstraZeneca, and Sputnik V vaccines, respectively. The patients who were treated with corticosteroids, IVIG, and anti-viral drugs, showed marked recovery afterward.
The rate ratio of Bell's palsy after COVID-19 vaccination was 25.3 per 1,000,000. The ratio was higher after the first dose compared to the second dose and was higher among those who took Oxford/AstraZeneca vaccine compared to other vaccines. However, this condition was reported in a small number of cases among a large number of vaccinated people worldwide. It is important to note that the benefits of getting vaccinated far outweigh any potential risks.
自宣布新冠疫情大流行以来，全世界都在寻找能够减缓疾病发展的线索。疫苗在减少疾病传播和拯救全球众多生命方面发挥着关键作用。然而，这些疫苗存在一些副作用，如疼痛、疲劳、发烧以及像贝尔氏面瘫这样的神经缺陷。在这项系统评价中，我们展示了新冠疫苗接种后贝尔氏面瘫发生情况的相关证据。
我们检索了从数据库创建至2022年10月的PubMed、SCOPUS、EBSCO和科学网（WOS）。使用乔安娜·布里格斯研究所、美国国立卫生研究院和纽卡斯尔-渥太华量表进行质量评估。分析在SPSS上进行。
我们的研究纳入了35条记录。我们的病例结果显示，大多数患者（62.8%）出现单侧面部麻痹。此外，大多数病例报告于首剂接种后，且多数病例分别出现在辉瑞、阿斯利康和卫星V疫苗接种之后。接受皮质类固醇、静脉注射免疫球蛋白和抗病毒药物治疗的患者随后显示出明显康复。
新冠疫苗接种后贝尔氏面瘫的发病率为每100万人中有25.3例。首剂接种后的发病率高于第二剂，接种牛津/阿斯利康疫苗者的发病率高于其他疫苗。然而，在全球大量接种疫苗的人群中，这种情况仅在少数病例中被报告。需要注意的是，接种疫苗的益处远远超过任何潜在风险。
