Universidad Continental, Lima, Perú.
Instituto Nacional de Salud del Niño San Borja, Lima, Perú.
Rev Peru Med Exp Salud Publica. 2023 Jan-Mar;40(1):111-114. doi: 10.17843/rpmesp.2023.401.12169. Epub 2023 Jun 23.
Recurrent respiratory papillomatosis is a neoplastic disease caused by the human papillomavirus and characterized by the growth of exophytic proliferative lesions affecting the mucosa of the respiratory tract. This condition has a bimodal age distribution; the juvenile form affects those under 20 years of age, is more aggressive and presents multiple papillomatous lesions and high frequency of recurrence, compared to the adult form. Pulmonary involvement is rare and challenging to treat. We present the case of a 13-year-old male with a history of laryngeal papillomatosis since the age of two years. The patient showed respiratory distress and multiple stenosing nodules in the larynx and trachea, as well as several pulmonary cysts identified on chest CT. The patient underwent excision of the papillomatous lesions and tracheostomy. Then, the patient received a single dose of intravenous bevacizumab 400 mg and respiratory therapies with favorable evolution, without recurrences during follow-up.
复发性呼吸道乳头瘤病是一种由人乳头瘤病毒引起的肿瘤性疾病，其特征是外生性增生性病变的生长，影响呼吸道的黏膜。这种疾病呈双峰年龄分布；青少年型发病年龄小于 20 岁，与成人型相比，其侵袭性更强，表现为多发性乳头状病变和高复发率。肺部受累罕见且难以治疗。我们报告了一例 13 岁男性病例，该患者自 2 岁起患有喉乳头瘤病。该患者出现呼吸窘迫，喉部和气管有多个狭窄性结节，胸部 CT 显示多个肺囊肿。该患者接受了乳头状病变切除术和气管造口术。随后，该患者接受了单次静脉注射贝伐珠单抗 400mg 治疗，并进行了呼吸治疗，病情好转，随访期间无复发。
