Bauman N M, Smith R J
Department of Otolaryngology-Head and Neck Surgery, University of Iowa College of Medicine, Iowa City, USA.
Pediatr Clin North Am. 1996 Dec;43(6):1385-401. doi: 10.1016/s0031-3955(05)70524-1.
Juvenile-onset recurrent respiratory papillomatosis is a vertically transmitted disease caused by members of the human papilloma virus family. Characterized by the relentless growth of papillomatous lesions of the larynx, recurrent respiratory papillomatosis imposes significant morbidity on patients and strain on their families. Surgical excision of the papillomata remains the mainstay of therapy, but human papilloma virus DNA persists in adjacent, normal-appearing mucosa and likely serves as a reservoir for viral reseeding. Despite multiple adjuvant treatment modalities, a cure for recurrent respiratory papillomatosis remains elusive. Most afflicted patients eventually enter spontaneous remission, but some endure several hundred surgical procedures before this welcome respite.
青少年复发性呼吸道乳头状瘤病是一种由人乳头瘤病毒家族成员引起的垂直传播疾病。复发性呼吸道乳头状瘤病的特征是喉部乳头状瘤病变持续生长，给患者带来严重的发病风险，并给其家庭带来负担。乳头状瘤的手术切除仍然是主要的治疗方法，但人乳头瘤病毒DNA在相邻的外观正常的黏膜中持续存在，很可能是病毒重新播种的来源。尽管有多种辅助治疗方式，但复发性呼吸道乳头状瘤病的治愈方法仍然难以捉摸。大多数患病患者最终会自行缓解，但有些患者在迎来这一可喜的缓解之前要忍受数百次外科手术。
