冠状动脉微血管功能障碍中的跨心肌ω-3脂肪酸梯度
Trans-myocardial omega-3 fatty acid gradient in coronary microvascular dysfunction.
作者信息
Keeley Ellen C, Handberg Eileen M, Noel Bairey Merz C, Pepine Carl J
机构信息
Department of Medicine, Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, United States of America.
Barbra Streisand Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States of America.
出版信息
Am Heart J Plus. 2022 Oct;22. doi: 10.1016/j.ahjo.2022.100213. Epub 2022 Sep 28.
BACKGROUND
Cardiac remodeling is a process mediated, in part, by 18-hydroxyeicosapentaenoic acid (HEPE), a metabolite of the omega-3 polyunsaturated fatty acid, eicosapentaenoic acid (EPA). We hypothesized that trans-myocardial levels of 18-HEPE could inform the pathophysiologic processes involved in heart failure with preserved ejection fraction (HFpEF).
METHODS
We measured the concentration of 18-HEPE and EPA in trans-myocardial plasma samples from 10 subjects enrolled in The Women's Ischemia Syndrome Evaluation [WISE] Mechanisms of Coronary Microvascular Dysfunction Leading to Pre-HFpEF project.
RESULTS
Concentrations of 18-HEPE were significantly lower in coronary venous compared to the aortic plasma (270.5 pg/mL [212.8-480.8] vs. 430.5 pg/mL [299.5-655.8], = 0.0039). There was a significant correlation between the concentrations of coronary venous EPA and aortic 18-HEPE ( = 0.94, = 0.0002), and aortic EPA and aortic 18-HEPE ( = 0.82, = 0.0058).
CONCLUSIONS
Results of this small pilot study support the suggestion that 18-HEPE is synthesized outside the heart and utilized within the myocardial bed.
背景
心脏重塑是一个部分由18-羟基二十碳五烯酸（18-HEPE）介导的过程，18-HEPE是ω-3多不饱和脂肪酸二十碳五烯酸（EPA）的一种代谢产物。我们假设经心肌的18-HEPE水平可以反映射血分数保留的心力衰竭（HFpEF）所涉及的病理生理过程。
方法
我们测量了参与“女性缺血综合征评估[WISE]导致HFpEF前期的冠状动脉微血管功能障碍机制”项目的10名受试者经心肌血浆样本中18-HEPE和EPA的浓度。
结果
与主动脉血浆相比，冠状动脉静脉血中18-HEPE的浓度显著降低（270.5 pg/mL [212.8 - 480.8] vs. 430.5 pg/mL [299.5 - 655.8]，P = 0.0039）。冠状动脉静脉血EPA浓度与主动脉18-HEPE浓度之间存在显著相关性（r = 0.94，P = 0.0002），以及主动脉EPA与主动脉18-HEPE之间也存在显著相关性（r = 0.82，P = 0.0058）。
结论
这项小型初步研究的结果支持以下观点，即18-HEPE在心脏外合成并在心肌床内被利用。
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