Baumgartner A, Gräf K J, Kürten I
Psychiatry Res. 1986 May;18(1):25-43. doi: 10.1016/0165-1781(86)90058-2.
Weekly dexamethasone suppression tests (DSTs) were performed in 35 patients with major depressive disorder until clinical response. At initial evaluation, 65% of the patients showed nonsuppression, and 85.7% showed nonsuppression at least once during the treatment period. Normalization of the DST results usually coincided with or occurred before clinical recovery, although isolated "peaks" of DST nonsuppression occurred in 45.7% of the patients, irrespective of the clinical course. The test was not useful as a predictor of clinical recovery or relapse. Moderately ill depressed patients had significantly higher nonsuppression rates than schizophrenic or manic patients with corresponding severity scores, indicating that different factors might be associated with nonsuppression in different diagnoses. However, many abnormal DST results could neither be related to the course of the depression nor to the severity of illness; thus other factors must also be responsible for DST nonsuppression.
对35例重度抑郁症患者进行了每周一次的地塞米松抑制试验（DST），直至出现临床反应。在初始评估时，65%的患者显示抑制功能丧失，85.7%的患者在治疗期间至少有一次显示抑制功能丧失。DST结果正常化通常与临床康复同时发生或在临床康复之前出现，尽管45.7%的患者出现了DST抑制功能丧失的孤立“峰值”，而与临床病程无关。该试验作为临床康复或复发的预测指标并无用处。中度抑郁患者的抑制功能丧失率显著高于具有相应严重程度评分的精神分裂症或躁狂症患者，这表明不同诊断中可能有不同因素与抑制功能丧失有关。然而，许多异常的DST结果既与抑郁症病程无关，也与疾病严重程度无关；因此，其他因素也必定是导致DST抑制功能丧失的原因。
