Targum S D
South Med J. 1984 Nov;77(11):1402-5. doi: 10.1097/00007611-198411000-00013.
The dexamethasone suppression test (DST) was given to 86 patients with unipolar depression at the time of admission to the hospital. Thirty-three patients (38%) had abnormal DST responses. There was no difference in treatment response or outcome between patients with normal or abnormal DST responses on admission. Of the 33 patients who had abnormal DST responses on admission, 25 (76%) showed normal responses by the time of discharge. Five of the eight patients (63%) with "persistent" nonsuppression despite symptomatic improvement and discharge had relapse within six months, while only four of 25 patients (16%) whose DST response became normal (P less than .05) and ten of 53 patients (19%) who had normal DSTs at the time of admission (P less than .05) had relapse. These findings suggest that persistence of abnormal DST responses may provide a useful prognostic marker of risk for early relapse in depressive disorder.
在86例单相抑郁症患者入院时对其进行了地塞米松抑制试验（DST）。33例患者（38%）的DST反应异常。入院时DST反应正常或异常的患者在治疗反应或结局方面没有差异。在入院时DST反应异常的33例患者中，25例（76%）在出院时显示反应正常。在8例尽管症状改善且已出院但仍“持续”不被抑制的患者中，有5例（63%）在6个月内复发，而DST反应变为正常的25例患者中只有4例（16%）（P<0.05）以及入院时DST正常的53例患者中有10例（19%）（P<0.05）复发。这些发现表明，DST反应异常的持续存在可能为抑郁症早期复发风险提供一个有用的预后指标。
