Baumgartner A, Haack D, Vecsei P
Psychiatry Res. 1986 May;18(1):45-64. doi: 10.1016/0165-1781(86)90059-4.
The effects of different intervening variables on dexamethasone suppression test (DST) results were evaluated in depressed, schizophrenic, and manic patients. There was a significant correlation between age and DST results in major depression. Some "isolated peaks" of DST nonsuppression were explained by low dexamethasone serum levels. In schizophrenic and manic patients, the dexamethasone concentrations increased to above the normal range during the study period. A significant negative correlation between dexamethasone concentrations and DST results was found in schizophrenia and mania, but not in depression. Dexamethasone levels were generally higher in men than in women. Weight loss and hospital admission affected the DST in individual cases, whereas length of episode and drug withdrawal did not. Thus, the intervening variables accounted for some of the abnormal DST results, but other factors such as severity of illness, nonspecific stress, or possibly depression itself emerged as the main causes of abnormal DST results.
在抑郁症、精神分裂症和躁狂症患者中评估了不同干预变量对地塞米松抑制试验（DST）结果的影响。在重度抑郁症中，年龄与DST结果之间存在显著相关性。一些DST不抑制的“孤立峰值”可由地塞米松血清水平低来解释。在精神分裂症和躁狂症患者中，地塞米松浓度在研究期间升高至正常范围以上。在精神分裂症和躁狂症中发现地塞米松浓度与DST结果之间存在显著负相关，但在抑郁症中未发现。男性的地塞米松水平通常高于女性。体重减轻和住院在个别病例中影响DST，而发作持续时间和停药则不影响。因此，干预变量解释了一些异常的DST结果，但其他因素，如疾病严重程度、非特异性应激或可能的抑郁症本身，成为异常DST结果的主要原因。
