Division of Organic and Medicinal Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, Wroclaw, Poland.
Front Immunol. 2023 Jun 12;14:1199427. doi: 10.3389/fimmu.2023.1199427. eCollection 2023.
There has been an increasing interest in using Immunoglobulin Y (IgY) antibodies as an alternative to "classical" antimicrobials. Unlike traditional antibiotics, they can be utilized on a continual basis without leading to the development of resistance. The veterinary IgY antibody market is growing because of the demand for minimal antibiotic use in animal production. IgY antibodies are not as strong as antibiotics for treating infections, but they work well as preventative agents and are natural, nontoxic, and easy to produce. They can be administered orally and are well tolerated, even by young animals. Unlike antibiotics, oral IgY supplements support the microbiome that plays a vital role in maintaining overall health, including immune system function. IgY formulations can be delivered as egg yolk powder and do not require extensive purification. Lipids in IgY supplements improve antibody stability in the digestive tract. Given this, using IgY antibodies as an alternative to antimicrobials has garnered interest. In this review, we will examine their antibacterial potential.
人们越来越感兴趣地使用免疫球蛋白 Y（IgY）抗体作为“经典”抗菌药物的替代品。与传统抗生素不同，它们可以持续使用而不会导致耐药性的产生。由于动物生产中对最小抗生素使用的需求，兽医 IgY 抗体市场正在增长。IgY 抗体在治疗感染方面不如抗生素强，但作为预防剂效果很好，而且天然、无毒且易于生产。它们可以口服，甚至可以被年幼的动物很好地耐受。与抗生素不同，口服 IgY 补充剂支持在维持整体健康（包括免疫系统功能）方面发挥重要作用的微生物组。IgY 制剂可以作为蛋黄粉提供，并且不需要广泛的纯化。IgY 补充剂中的脂质可提高抗体在消化道中的稳定性。考虑到这一点，使用 IgY 抗体作为抗菌药物的替代品引起了人们的兴趣。在这篇综述中，我们将研究它们的抗菌潜力。
Zotero 插件