Murray Michelle A, Mulryan Kathryn, Ní Chléirigh Maedhbh, Redmond Karen C, Kelly Emer
School of Medicine and Medical Science, University College Dublin, Dublin, Ireland.
Mater Misericordiae University Hospital, Dublin, Ireland.
Breathe (Sheff). 2023 Mar;19(1):220229. doi: 10.1183/20734735.0229-2022. Epub 2023 May 23.
COPD affects millions of people worldwide. Patients with advanced COPD have a high symptom burden. Breathlessness, cough and fatigue are frequent daily symptoms. Guidelines often focus on pharmacological treatment, especially inhaler therapy, but other approaches in combination with medications offer symptomatic benefit. In this review, we take a multidisciplinary approach with contributions from pulmonary physicians, cardiothoracic surgeons and a physiotherapist. The following areas are addressed: oxygen therapy and noninvasive ventilation (NIV), dyspnoea management, surgical and bronchoscopic options, lung transplantation and palliative care. Oxygen therapy prescribed within guidelines improves mortality in patients with COPD. NIV guidelines offer only low-certainty instruction on the use of this therapy on the basis of the limited available evidence. Dyspnoea management can take place through pulmonary rehabilitation. Specific criteria aid decisions on referral for lung volume reduction treatments through surgical or bronchoscopic approaches. Lung transplantation requires precise disease severity assessment to determine which patients have the most urgent need for lung transplantation and are likely to have the longest survival. The palliative approach runs in parallel with these other treatments, focusing on symptoms and aiming to improve the quality of life of patients and their families facing the problems associated with life-threatening illness. In combination with appropriate medication and an individual approach to symptom management, patients' experiences can be optimised.
To understand the multidisciplinary approach to management of patients with advanced COPD.To recognise the parallel approaches to oxygen, NIV and dyspnoea management with consideration of more interventional options with lung volume reduction therapy or lung transplantation.To understand the high level of symptomatology present in advanced COPD and the relevance of palliative care alongside optimal medical management.
慢性阻塞性肺疾病(COPD)影响着全球数百万人。晚期COPD患者症状负担沉重。呼吸困难、咳嗽和疲劳是常见的日常症状。指南通常侧重于药物治疗,尤其是吸入器疗法,但与药物联合的其他方法也能带来症状改善。在本综述中,我们采用了多学科方法,汇集了肺科医生、心胸外科医生和物理治疗师的意见。探讨了以下领域:氧疗和无创通气(NIV)、呼吸困难管理、手术和支气管镜治疗选择、肺移植和姑息治疗。按照指南规定进行的氧疗可降低COPD患者的死亡率。基于有限的现有证据,NIV指南对该疗法的使用仅提供低确定性的指导。呼吸困难管理可通过肺康复进行。特定标准有助于决定通过手术或支气管镜方法转诊接受肺减容治疗。肺移植需要精确评估疾病严重程度,以确定哪些患者最急需肺移植且可能存活时间最长。姑息治疗方法与这些其他治疗并行,关注症状,旨在提高面临危及生命疾病相关问题的患者及其家人的生活质量。结合适当的药物治疗和针对症状管理的个体化方法,可优化患者体验。
了解晚期COPD患者管理的多学科方法。认识到氧疗、NIV和呼吸困难管理的并行方法,并考虑肺减容治疗或肺移植等更多介入性选择。理解晚期COPD中存在的高水平症状学以及姑息治疗与最佳药物治疗并行的相关性。