Lin Hanqing, Wang Yalong, Cheng Chunyan, Qian Yuxin, Hao Jie, Zhang Zhen, Sheng Weiqi, Song Linhong, Deng Chu-Xia, Zhao Bing, Cao Jiani, Wang Lei, Wang Liu, Liang Lingmin, Chen Wenli Kelly, Yu Chunping, Sun Zhijian, Yang Yingying, Wang Changlin, Zhang Yong, Li Qiyuan, Li Ka, Ma Aijin, Zhao Tongbiao, Chen Ye-Guang, Hua Guoqiang
D1Med Technology (Shanghai) Inc, Shanghai, 201802, China.
The State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Cell Regen. 2023 Jun 28;12(1):24. doi: 10.1186/s13619-023-00167-6.
Intestinal cancer is one of the most frequent and lethal types of cancer. Modeling intestinal cancer using organoids has emerged in the last decade. Human intestinal cancer organoids are physiologically relevant in vitro models, which provides an unprecedented opportunity for fundamental and applied research in colorectal cancer. "Human intestinal cancer organoids" is the first set of guidelines on human intestinal organoids in China, jointly drafted and agreed by the experts from the Chinese Society for Cell Biology and its branch society: the Chinese Society for Stem Cell Research. This standard specifies terms and definitions, technical requirements, test methods for human intestinal cancer organoids, which apply to the production and quality control during the process of manufacturing and testing of human intestinal cancer organoids. It was released by the Chinese Society for Cell Biology on 24 September 2022. We hope that the publication of this standard will guide institutional establishment, acceptance and execution of proper practocal protocols, and accelerate the international standardization of human intestinal cancer organoids for clinical development and therapeutic applications.
肠癌是最常见且致命的癌症类型之一。在过去十年中，利用类器官建模肠癌的技术应运而生。人肠癌类器官是具有生理相关性的体外模型，为结直肠癌的基础研究和应用研究提供了前所未有的机遇。《人肠癌类器官》是我国首部关于人肠道类器官的指南，由中国细胞生物学学会及其分支学会——中国干细胞研究学会的专家共同起草并商定。本标准规定了人肠癌类器官的术语和定义、技术要求、检测方法，适用于人肠癌类器官生产及检测过程中的生产和质量控制。该标准于2022年9月24日由中国细胞生物学学会发布。我们希望本标准的发布将指导相关机构建立、认可和执行合适的实践方案，并加速人肠癌类器官临床开发和治疗应用的国际标准化进程。
