Tan Ronghui, Hong Fan, Wang Ting, Zhong Nanshan, Zhao Hongling, Xu Rui-Hua, Shen Lin, Liu Yingbin, Yao Xuebiao, Xiang Dongxi, Gao Dong, Xiong Jianping, Hui Lijian, Zhao Bing, Miao Zhifeng, Hao Jie, Li Yong, Hu Shijun, Fu Boqiang, Hua Guoqiang, Wang Lei, Zeng Zhao-Lei, Chen Chong, Wu Jianmin, Wang Changlin, Wang Chunnian, Zhan Xianbao, Song Chen, Sun Zhijian, Yu Chunping, Yang Yingying, Niu Gengming, Wang Yalong, Zhao Tongbiao, Chen Ye-Guang
Guangzhou National Laboratory, Guangzhou, 510005, China.
The State Key Laboratory of Membrane Biology, Tsinghua‑Peking Center for Life Sciences,, School of Life Sciences , Tsinghua University, Beijing, 100084, China.
Cell Regen. 2024 Dec 27;13(1):33. doi: 10.1186/s13619-024-00217-7.
Gastric cancer is one of the most common malignancies with poor prognosis. The use of organoids to simulate gastric cancer has rapidly developed over the past several years. Patient-derived gastric cancer organoids serve as in vitro models that closely mimics donor characteristics, offering new opportunities for both basic and applied research. The "Human Gastric Cancer Organoid" is part of a series of guidelines for human gastric cancer organoids in China, jointly drafted by experts from the Chinese Society for Cell Biology and its branches, and initially released on October 29, 2024. This standard outlines terminology, technical requirements, assessment protocols, and applies to production, evaluation procedures, and quality control for human gastric cancer organoids. The publication of this guideline aims to assist institutions in endorsing, establishing, and applying best practices, advancing the international standardization of human gastric cancer organoids for clinical development and therapeutic application.
胃癌是最常见的恶性肿瘤之一，预后较差。在过去几年中，利用类器官模拟胃癌的技术发展迅速。患者来源的胃癌类器官作为体外模型，能紧密模拟供体特征，为基础研究和应用研究都提供了新机遇。《人胃癌类器官》是中国细胞生物学学会及其分会专家联合起草的中国胃癌类器官系列指南的一部分，于2024年10月29日首次发布。本标准规定了术语、技术要求、评估方案，适用于人胃癌类器官的生产、评价程序及质量控制。本指南的发布旨在帮助各机构认可、建立和应用最佳实践，推动人胃癌类器官临床开发和治疗应用的国际标准化。
