Department of Oral Mucosa, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China; Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China.
Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China.
Arch Oral Biol. 2023 Sep;153:105751. doi: 10.1016/j.archoralbio.2023.105751. Epub 2023 Jun 17.
This study was presented to reveal the most distinct microbial prevalence in recurrent aphthous stomatitis (RAS) lesions compared to healthy controls.
The case-control studies were selected in electronic databases until Nov 2022 with key search terms, and the eligible publications were screened and analyzed by independent authors.
A total of 14 studies were identified, which included 531 cases of active states of RAS (AS-RAS), 92 cases of passive states of RAS (PS-RAS) and 372 healthy controls. The most sample pattern was the mucosa swab performed in 8 of 14 studies, biopsies in 3 studies, followed by micro-brush, and saliva. A variety of bacteria in higher or lower abundance were observed in RAS lesions.
The etiopathogenesis of RAS may not be ascribed to a single pathogen. A possible explanation is that microbial interactions modify immune response or destroy the epithelial integrity, thus contributing to the development of the condition.
本研究旨在揭示复发性阿弗他溃疡（RAS）病变与健康对照组相比，最显著的微生物流行情况。
本研究纳入了电子数据库中截至 2022 年 11 月的病例对照研究，并使用了关键检索词，由独立作者对合格的出版物进行了筛选和分析。
共确定了 14 项研究，其中包括 531 例 RAS 活动期（AS-RAS）、92 例 RAS 静止期（PS-RAS）和 372 例健康对照。在 14 项研究中，最常见的样本采集方式是黏膜拭子（8 项研究）、活检（3 项研究），其次是微刷和唾液。在 RAS 病变中观察到多种细菌的丰度增加或减少。
RAS 的发病机制可能不是由单一病原体引起的。一种可能的解释是，微生物相互作用改变了免疫反应或破坏了上皮完整性，从而导致该疾病的发生。
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