The first clinical college, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Institute of Basic Research in Clinical Medicine, College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Medicine (Baltimore). 2021 Mar 12;100(10):e24742. doi: 10.1097/MD.0000000000024742.
Oral microbiota has been implicated in pathogenesis of recurrent aphthous stomatitis (RAS), which is a common mucosal disorder with unclear etiology. This study has explored the association between oral microbiota disorder and RAS in high-risk young female population.Forty-five young females were enrolled, including 24 RAS patients and 21 healthy individuals. Oral microbiome was analyzed by Illumina Miseq sequencing.Oral microbiota associated with RAS was characterized by the lower alpha-diversity indices (Chao1 and ACE). Several infectious pathogens increased in RAS, such as genera Actinobacillus, Haemophilus, Prevotella and Vibrio. The PICRUSt analysis indicated that the oral microbiota might be related with the up-regulation of genes involving infectious and neurodegenerative diseases, environmental adaptation, the down-regulation of genes involving basal metabolism, such as carbohydrate, energy, and amino acid metabolism.This study indicated that oral microbiota may play a significant role in RAS development.
口腔微生物群与复发性阿弗他口腔炎（RAS）的发病机制有关，RAS 是一种病因不明的常见黏膜疾病。本研究探讨了高危年轻女性人群中口腔微生物群紊乱与 RAS 之间的关系。
纳入了 45 名年轻女性，包括 24 名 RAS 患者和 21 名健康个体。通过 Illumina Miseq 测序分析口腔微生物组。
RAS 相关的口腔微生物群的特征是较低的 alpha 多样性指数（Chao1 和 ACE）。RAS 中几种感染性病原体增加，如 Actinobacillus、Haemophilus、Prevotella 和 Vibrio 属。PICRUSt 分析表明，口腔微生物群可能与涉及感染和神经退行性疾病、环境适应的基因上调，以及涉及碳水化合物、能量和氨基酸代谢等基础代谢的基因下调有关。
本研究表明，口腔微生物群可能在 RAS 的发展中起重要作用。
