Hilary Serene, Mohamed Ozaz, Platat Carine, Qureshi Muhammad A, Kizhakkayil Jaleel, Al-Meqbaali Fatima, Howarth Frank C
Department of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, PO Box 15551, Al Ain, United Arab Emirates.
Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, PO Box 15551, Al Ain, United Arab Emirates.
Heliyon. 2023 Jun 15;9(6):e17313. doi: 10.1016/j.heliyon.2023.e17313. eCollection 2023 Jun.
This study investigated the differences in health outcomes associated with ferulic acid (FA) supplementation in animals before the induction of diabetes with streptozotocin (STZ) treatment and post-STZ treatment. 18 male Wistar rats were equally distributed into three groups: groups 1 and 2 received FA (50 mg/kg body weight) supplementation one week before STZ treatment (60 mg/kg body weight, intraperitoneal) and one week after STZ treatment, respectively; group 3 received STZ without FA supplementation. FA supplementation was continued for 12 weeks after STZ treatment. The results indicated no difference in glucose and lipid profile with FA supplementation. However, FA supplementation reduced lipid and protein oxidative damage in the heart, liver and pancreas and increased glutathione in the pancreas. The results indicate that while oxidative damages were positively affected by FA, it was not sufficient to improve metabolic markers of diabetes.
本研究调查了在链脲佐菌素（STZ）诱导糖尿病之前及之后补充阿魏酸（FA）对动物健康结果的差异。18只雄性Wistar大鼠被平均分为三组：第1组和第2组分别在STZ治疗（60mg/kg体重，腹腔注射）前一周和STZ治疗后一周接受FA（50mg/kg体重）补充；第3组接受无FA补充的STZ治疗。STZ治疗后FA补充持续12周。结果表明，补充FA对血糖和血脂水平无差异。然而，补充FA可降低心脏、肝脏和胰腺中的脂质和蛋白质氧化损伤，并增加胰腺中的谷胱甘肽。结果表明，虽然氧化损伤受到FA的积极影响，但不足以改善糖尿病的代谢指标。
