Chengdu University of Traditional Chinese Medicine, Key Laboratory Breeding Base of Systematic Research and Utilization on Chinese Material Medical Resources, Chengdu 611137, China.
Chengdu University of Traditional Chinese Medicine, Key Laboratory Breeding Base of Systematic Research and Utilization on Chinese Material Medical Resources, Chengdu 611137, China.
Life Sci. 2021 Nov 1;284:119921. doi: 10.1016/j.lfs.2021.119921. Epub 2021 Sep 3.
Ferulic acid, a kind of phenolic substance widely existing in plants, is an important active component of many traditional Chinese medicines. So far, it has been proved that ferulic acid has a variety of biological activities, especially in oxidative stress, inflammation, vascular endothelial injury, fibrosis, apoptosis and platelet aggregation. Many studies have shown that ferulic acid can inhibit PI3K/AKT pathway, the production of ROS and the activity of aldose reductase. The anti-inflammatory effect of ferulic acid is mainly related to the levels of PPAR γ, CAM and NF-κ B and p38 MAPK signaling pathways. Ferulic acid not only protects vascular endothelium by ERK1/2 and NO/ET-1 signal, but also plays an anti-fibrosis role by TGF-β/Smad and MMPs/TIMPs system. Moreover, ferulic acid has ant-apoptotic and anti-platelet effects. In addition to the pharmacological effects of ferulic acid, its pharmacokinetics and derivatives were also discussed in this paper. This review provides the latest summary of the latest research on ferulic acid.
阿魏酸是一种广泛存在于植物中的酚类物质，是许多中药的重要活性成分。到目前为止，已经证明阿魏酸具有多种生物活性，特别是在氧化应激、炎症、血管内皮损伤、纤维化、细胞凋亡和血小板聚集方面。许多研究表明，阿魏酸可以抑制 PI3K/AKT 通路、ROS 的产生和醛糖还原酶的活性。阿魏酸的抗炎作用主要与 PPARγ、CAM 和 NF-κB 及 p38MAPK 信号通路有关。阿魏酸不仅通过 ERK1/2 和 NO/ET-1 信号保护血管内皮，还通过 TGF-β/Smad 和 MMPs/TIMPs 系统发挥抗纤维化作用。此外，阿魏酸具有抗细胞凋亡和抗血小板作用。除了阿魏酸的药理学作用外，本文还讨论了其药代动力学和衍生物。本综述提供了阿魏酸最新研究的最新总结。
