Mirchev Milko Bozhidarov, Boeva Irina, Peshevska-Sekulovska Monika, Stoitsov Veselin, Peruhova Milena
Department of Gastroenterology, Heart and Brain Hospital, Burgas 8000, Bulgaria.
Department of Gastroenterology, University Hospital Lozenetz, Sofia 1407, Bulgaria.
World J Clin Cases. 2023 May 26;11(15):3408-3417. doi: 10.12998/wjcc.v11.i15.3408.
High rates of extrapancreatic malignancies, in particular colorectal cancer (CRC), have been detected in patients with intraductal papillary mucinous neoplasm (IPMN). So far, there is no distinct explanation in the literature for the development of secondary or synchronous malignancies in patients with IPMN. In the past few years, some data related to common genetic alterations in IPMN and other affiliated cancers have been published. This review elucidated the association between IPMN and CRC, shedding light on the most relevant genetic alterations that may explain the possible relationship between these entities. In keeping with our findings, we suggested that once the diagnosis of IPMN is made, special consideration of CRC should be undertaken. Presently, there are no specific guidelines regarding colorectal screening programs for patients with IPMN. We recommend that patients with IPMNs are at high-risk for CRC, and a more rigorous colorectal surveillance program should be implemented.
在导管内乳头状黏液性肿瘤（IPMN）患者中已检测到较高的胰腺外恶性肿瘤发生率，尤其是结直肠癌（CRC）。迄今为止，文献中尚无关于IPMN患者发生继发性或同步性恶性肿瘤的明确解释。在过去几年中，已发表了一些与IPMN及其他相关癌症常见基因改变有关的数据。本综述阐明了IPMN与CRC之间的关联，揭示了可能解释这些实体之间潜在关系的最相关基因改变。与我们的研究结果一致，我们建议一旦诊断出IPMN，就应特别考虑CRC。目前，对于IPMN患者的结直肠癌筛查计划尚无具体指南。我们建议IPMN患者患CRC的风险较高，应实施更严格的结直肠癌监测计划。
