Department of General Practice, Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu, China.
Department of Nutrition, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Clin Nutr. 2023 Aug;42(8):1308-1313. doi: 10.1016/j.clnu.2023.06.017. Epub 2023 Jun 22.
Growing evidence has indicated that alterations in the gut microbiota and nutritional quality of dietary intake were associated with COVID-19. Whether these associations reflect causality is still unknown.
We performed a two-sample Mendelian randomization analysis using genetic variants as instrumental variables for gut microbiota, dietary component intake, and COVID-19.
We found that the Ruminococcustorques group genus was significantly associated with COVID-19. The Ruminococcaceae UCG013 genus and Ruminococcus1 genus were suggestively associated with COVID-19. The Actinobacteria class, Bifidobacteriales order, Bifidobacteriaceae genus, R. group, and Tyzzerella3 genus were potentially associated with severe COVID-19. COVID-19 was significantly associated with the Lachnospira genus, Oscillospira, and RuminococcaceaeUCG009 genus and potentially associated with the Victivallis genus. Severe COVID-19 was significantly associated with the Turicibacter and Olsenella genus and potentially associated with Ruminococcus1, CandidatusSoleaferrea, and Parasutterella genus. Moreover, processed meat intake was significantly associated with COVID-19. Beef intake was suggestively associated with COVID-19. Salt added to food intake, and fresh fruit intake was suggestively associated with severe COVID-19.
Our findings provide evidence supporting a causal effect of gut microbiota and dietary intake on COVID-19. We also found the causal effect of COVID-19 on the alteration of gut microbiota.
越来越多的证据表明，肠道微生物群的改变和饮食摄入的营养质量与 COVID-19 有关。这些关联是否反映了因果关系尚不清楚。
我们使用遗传变异作为肠道微生物群、饮食成分摄入和 COVID-19 的工具变量，进行了两样本孟德尔随机化分析。
我们发现 Ruminococcustorques 属与 COVID-19 显著相关。Ruminococcaceae UCG013 属和 Ruminococcus1 属与 COVID-19 呈提示性相关。厚壁菌门、双歧杆菌目、双歧杆菌科、R 组和 Tyzzerella3 属与严重 COVID-19 呈潜在相关。COVID-19 与 Lachnospira 属、Oscillospira 属和 Ruminococcaceae UCG009 属显著相关，与 Victivallis 属呈潜在相关。严重 COVID-19 与 Turicibacter 和 Olsenella 属显著相关，与 Ruminococcus1、CandidatusSoleaferrea 和 Parasutterella 属呈潜在相关。此外，加工肉类摄入与 COVID-19 显著相关。牛肉摄入与 COVID-19 呈提示性相关。食物中添加的盐和新鲜水果摄入与严重 COVID-19 呈提示性相关。
我们的研究结果提供了支持肠道微生物群和饮食摄入对 COVID-19 具有因果关系的证据。我们还发现 COVID-19 对肠道微生物群改变的因果效应。
