Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Exp Dermatol. 2024 Sep;33(9):e15176. doi: 10.1111/exd.15176.
Previous observational studies have suggested that gut microbiota might be associated with vitiligo. However, owing to the limitations in observational studies of reverse causality and confounders, it remains unclear that whether and how the causal relationships exist. The results suggested that pylum.Bacteroidetes, family.BacteroidalesS24.7, genus.LachnospiraceaeND3007, genus.Marvinbryantia are protective factors for vitiligo. Conversely, family.Lachnospiraceae, order.Burkholderiales, genus.Adlercreutzia, genus.Catenibacterium and genus.Lachnospira are risk factors for vitiligo. In addition, the causative connection between dietary factors and the gut microbiota associated with vitiligo was also investigated. The results revealed that 'alcohol intake versus 10 years pervious' results in a reduction in the abundance of genus.Lachnospiraceae ND3007 and family.BacteroidalesS24.7, bread intake leads to a reduction of genus.Marvinbryantia, 'average weekly red wine intake' is linked to a decrease in the abundance of order.Burkholderiales, tea intake is associated with an augmentation in the abundance of genus.Catenibacterium, salad/raw vegetable intake elevates the abundance of order.Burkholderiales. In summary, this Mendelian randomization study substantiates potential causal effects of gut microbiota on vitiligo. Modulating the gut microbiota through regulating dietary composition may be a novel strategy for preventing vitiligo.
先前的观察性研究表明，肠道微生物群可能与白癜风有关。然而，由于观察性研究中存在反向因果关系和混杂因素的限制，尚不清楚是否以及如何存在因果关系。结果表明，门。拟杆菌门、科。拟杆菌科 S24.7、属。lachnospiraceaeND3007、属。Marvinbryantia 是白癜风的保护因素。相反，科。lachnospiraceae、目。伯克霍尔德氏菌目、属。Adlercreutzia、属。Catenibacterium 和属。lachnospira 是白癜风的危险因素。此外，还研究了饮食因素与与白癜风相关的肠道微生物群之间的因果关系。结果表明，“饮酒量与 10 年前相比”导致属。lachnospiraceae ND3007 和科。拟杆菌科 S24.7 的丰度降低，摄入面包导致属。Marvinbryantia 减少，“平均每周红酒摄入量”与属。伯克霍尔德氏菌目减少有关，摄入茶与属。Catenibacterium 的丰度增加有关，摄入沙拉/生蔬菜会增加属。伯克霍尔德氏菌目的丰度。总之，这项孟德尔随机化研究证实了肠道微生物群对白癜风的潜在因果影响。通过调节饮食成分来调节肠道微生物群可能是预防白癜风的一种新策略。
