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FLASH-RT 对突触可塑性的保护效应在标准分割的小鼠中得以维持。

The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation.

机构信息

Department of Radiation Oncology, University of California, Irvine, CA 92697-2695, USA.

Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.

出版信息

Radiother Oncol. 2023 Sep;186:109767. doi: 10.1016/j.radonc.2023.109767. Epub 2023 Jun 28.

DOI:10.1016/j.radonc.2023.109767
PMID:37385377
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11045040/
Abstract

Long-term potentiation (LTP) was used to gauge the impact of conventional and FLASH dose rates on synaptic transmission. Data collected from the hippocampus and medial prefrontal cortex confirmed significant inhibition of LTP after 10 fractions of 3 Gy (30 Gy total) conventional radiotherapy. Remarkably, 10x3Gy FLASH radiotherapy and unirradiated controls were identical and exhibited normal LTP.

摘要

长时程增强（LTP）被用来评估常规剂量率和 FLASH 剂量率对突触传递的影响。从海马体和内侧前额叶皮层收集的数据证实，在接受 10 次 3Gy（总剂量 30Gy）常规放射治疗后，LTP 受到显著抑制。值得注意的是，10 次 3Gy 的 FLASH 放射治疗和未经照射的对照组完全相同，表现出正常的 LTP。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7670/11045040/04ccbc964a7b/nihms-1984527-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7670/11045040/9dfc3e381ad2/nihms-1984527-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7670/11045040/04ccbc964a7b/nihms-1984527-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7670/11045040/9dfc3e381ad2/nihms-1984527-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7670/11045040/04ccbc964a7b/nihms-1984527-f0002.jpg

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3
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Brain Struct Funct. 2025 Mar 1;230(2):41. doi: 10.1007/s00429-025-02902-y.
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