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用于VHEE SAFEST项目的紧凑型C波段FLASH电子直线加速器原型。

A compact C-band FLASH electron linear accelerator prototype for the VHEE SAFEST project.

作者信息

Giuliano Lucia, Alesini David, Cardelli Fabio, Carillo Martina, Chiadroni Enrica, Coppola Massimiliano, Cuttone Giacomo, Curcio Alessandro, De Gregorio Angelica, Raddo Roberto Di, Faillace Luigi, Farina Stefano, Ficcadenti Luca, Francescone Daniele, Franciosini Gaia, Franzini Giovanni, Gallo Alessandro, Magi Marco, Mauro Giorgio S, Mostacci Andrea, Palumbo Luigi, Patera Vincenzo, Perondi Francesca, Petrarca Massimo, Pioli Stefano, Remetti Romolo, Sarti Alessio, Schiavi Angelo, Spataro Bruno, Torrisi Giuseppe, Vannozzi Alessandro, Migliorati Mauro

机构信息

Scienze di Base e Applicate per l'Ingegneria (SBAI) Department, Sapienza University of Rome, Rome, Italy.

Sec. Roma1 of Istituto Nazionale di Fisica Nucleare, Rome, Italy.

出版信息

Front Oncol. 2025 Mar 6;15:1516576. doi: 10.3389/fonc.2025.1516576. eCollection 2025.

DOI:10.3389/fonc.2025.1516576
PMID:40134606
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11934386/
Abstract

FLASH therapy, a novel cancer treatment technique, aims to control tumor growth, sparing the healthy tissue from radiation damage and thus increasing the therapeutic ratio. Translating FLASH therapy into clinical practice, especially for treating deep-seated tumors, necessitates achieving Very High-Energy Electron (VHEE) levels within the 50-250 MeV range. In 2022 Sapienza University, in collaboration with INFN, launched the SAFEST project, a compact C-band 100 MeV Ultra-High Dose Rate (UHRD) radiation source for the treatment of deep-seated tumors, which was partially funded by Italian PNRR (Next Generation EU). A C-band linac prototype at lower energy, with an electron pulse of 100 nC and repetition frequency <200 Hz, is being developed to test the key choices and technology of a VHEE machine. This paper provides insights into the design strategy of the prototype, discussing the optimization of the main RF and electron beam parameters. The expected dose profiles are also shown and discussed. The progress of this innovative linac represents a step forward in the realization of a C-band compact FLASH VHEE source for cancer treatment.

摘要

FLASH疗法是一种新型癌症治疗技术，旨在控制肿瘤生长，使健康组织免受辐射损伤，从而提高治疗比。将FLASH疗法应用于临床实践，尤其是治疗深部肿瘤，需要达到50-250兆电子伏特范围内的超高能电子（VHEE）水平。2022年，罗马第一大学与意大利国家核物理研究所合作启动了SAFEST项目，这是一种用于治疗深部肿瘤的紧凑型C波段100兆电子伏特超高剂量率（UHRD）辐射源，该项目部分由意大利复苏与韧性计划（下一代欧盟）资助。正在开发一种能量较低的C波段直线加速器原型，其电子脉冲为100纳库仑，重复频率<200赫兹，以测试VHEE机器的关键选择和技术。本文深入探讨了该原型的设计策略，讨论了主要射频和电子束参数的优化。还展示并讨论了预期的剂量分布。这种创新型直线加速器的进展代表了在实现用于癌症治疗的C波段紧凑型FLASH VHEE源方面向前迈出的一步。

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本文引用的文献

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Reinventing Radiobiology in the Light of FLASH Radiotherapy.基于FLASH放射治疗重塑放射生物学。
Annu Rev Cancer Biol. 2023 Apr;7:1-21. doi: 10.1146/annurev-cancerbio-061421-022217. Epub 2023 Jan 11.
2
The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation.FLASH-RT 对突触可塑性的保护效应在标准分割的小鼠中得以维持。
Radiother Oncol. 2023 Sep;186:109767. doi: 10.1016/j.radonc.2023.109767. Epub 2023 Jun 28.
3
Perspectives in linear accelerator for FLASH VHEE: Study of a compact C-band system.
用于FLASH VHEE的直线加速器展望：紧凑型C波段系统研究
Phys Med. 2022 Dec;104:149-159. doi: 10.1016/j.ejmp.2022.10.018. Epub 2022 Nov 23.
4
GPU-accelerated Monte Carlo simulation of electron and photon interactions for radiotherapy applications.用于放射治疗应用的 GPU 加速电子和光子相互作用的蒙特卡罗模拟。
Phys Med Biol. 2023 Feb 15;68(4). doi: 10.1088/1361-6560/aca1f2.
5
Proton FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases: The FAST-01 Nonrandomized Trial.质子 FLASH 放疗治疗症状性骨转移：FAST-01 非随机试验。
JAMA Oncol. 2023 Jan 1;9(1):62-69. doi: 10.1001/jamaoncol.2022.5843.
6
Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs.FLASH 放疗在鼻腔平面鳞状细胞癌猫和小型猪中剂量和体积限制的晚期毒性。
Clin Cancer Res. 2022 Sep 1;28(17):3814-3823. doi: 10.1158/1078-0432.CCR-22-0262.
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A Data-Driven Fragmentation Model for Carbon Therapy GPU-Accelerated Monte-Carlo Dose Recalculation.一种用于碳疗法的基于数据驱动的碎片化模型：GPU加速的蒙特卡罗剂量重新计算
Front Oncol. 2022 Mar 25;12:780784. doi: 10.3389/fonc.2022.780784. eCollection 2022.
8
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Front Oncol. 2021 Dec 23;11:777852. doi: 10.3389/fonc.2021.777852. eCollection 2021.
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