Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Diagn Pathol. 2023 Jun 29;18(1):77. doi: 10.1186/s13000-023-01366-0.
Ligneous conjunctivitis (LC) is a rare inflammatory lesion of the conjunctiva with an unknown etiology. It is easily confused with conjunctiva lymphoma or other diseases in clinical diagnosis, and the lesion is very difficult to treat.
We presented a 41-year-old female patient presented with bilateral conjunctival masses for more than six months. The patient had no contributory history of ocular trauma, family history of tumor and drug allergy. Taking the patient's clinical and pathological features together, we considered this was a case of IgG4 + LC. Completely surgical resection combined with local glucocorticoid treatment might be effective.
This is a very rare case report of immunoglobulin G4 positive LC with only one published case in literature. The typical manifestations of LC are with the appearance of a hard, fibrin-rich, woody pseudomembranous lesion. A large number of lymphocyte and plasma cell are infiltrated in the pathological tissue. Inflammation of LC may cause immune abnormalities, resulting in IgG4 increasing.
细菌性结膜炎（LC）是一种罕见的结膜炎症性病变，病因不明。在临床诊断中，它很容易与结膜淋巴瘤或其他疾病混淆，病变也很难治疗。
我们报告了一例 41 岁女性患者，双侧结膜肿块 6 个多月。患者无眼部外伤史、肿瘤家族史和药物过敏史。根据患者的临床和病理特征，我们考虑这是一例 IgG4+LC。完全手术切除联合局部糖皮质激素治疗可能有效。
这是一例非常罕见的免疫球蛋白 G4 阳性 LC 病例报告，文献中仅发表过一例。LC 的典型表现为坚硬、富含纤维蛋白、木质样假膜性病变。在病理组织中大量淋巴细胞和浆细胞浸润。LC 的炎症可能导致免疫异常，导致 IgG4 增加。
