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67 岁男性患者白内障术后复发性 ligneous 结膜炎:病例报告。

Recurrent ligneous conjunctivitis after cataract surgery in a 67-year-old male patient: a case report.

机构信息

Department of Ophthalmology, Saarland University Medical Center, Kirrbergerstraße 100, Bld. 22, 66421, Homburg/Saar, Germany.

Department of General and Special Pathology, Saarland University Medical Center, Homburg/Saar, Germany.

出版信息

BMC Ophthalmol. 2022 Mar 5;22(1):103. doi: 10.1186/s12886-022-02329-7.

DOI:10.1186/s12886-022-02329-7
PMID:35247993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8897893/
Abstract

BACKGROUND

Ligneous conjunctivitis is a rare form of chronic pseudomembranous conjunctivitis which usually starts during infancy. We report on an unsual case of recurrent ligneous conjunctivitis after cataract surgery in a 67-year-old male patient.

METHODS

The equipment used for the slit-lamp images was a Haag Streit slit lamp BX900 Sn 00,406 with 16 × magnifications. The used batch number of the camera was sn00406 and the software was from the company CCS Pawlowski Merge Eye. There were no filters used. The images were saved with a resolution of 300 DPI. Neither downstream nor averaging was used to enhance the resolution of the image in the case presentation section or the figure legend. The equipment used for the cross-sectional histologic images was a Zeiss Axioskop 40 microscope with an objective lens Zeiss A-Plan × 20/0.45 (Zoom 6.3 × TV 2/3″″C). The used camera was AxioCam MRc5 and the software was ZEN 3.2. The cross-sectional histologic images were saved with a resolution of 2584 × 1936 Pixels. Neither downstream nor averaging was used to enhance the resolution of the image in the case presentation section or the figure legend.

CASE PRESENTATION

This is a rare case report of ligneous conjunctivitis in a 67-year-old male patient who presented a recurrent conjunctival granuloma after five excisions following cataract surgery in his left eye. We performed a tumor excision with free conjunctival autograft. The histology showed a fibrin crust including macrophages, granulocytes, lymphocytes, and reactively altered squamous cell nests. These findings were consistent with a ″pseudomembrane in conjunctivitis lignosa″. We administered a topical combination of plasminactivator, heparin, cortisone and cyclosporine.

CONCLUSION

This treatment with the combination of plasminactivator, heparin, cortisone and cyclosporine has proven to be effective in preventing the recurrence of ligneous conjunctivitis.

摘要

背景

细菌性结膜炎是一种罕见的慢性假膜性结膜炎,通常在婴儿期开始。我们报告了一例 67 岁男性患者在白内障手术后反复发作细菌性结膜炎的罕见病例。

方法

裂隙灯图像使用 Haag Streit 裂隙灯 BX900 Sn 00,406,放大倍率为 16×。使用的相机批次号为 sn00406,软件来自 CCS Pawlowski Merge Eye 公司。图像中未使用任何滤镜。图像以 300 DPI 的分辨率保存。在病例介绍部分或图例中,既未使用下游处理也未使用平均处理来提高图像的分辨率。 横断面组织学图像使用 Zeiss Axioskop 40 显微镜和 Zeiss A-Plan × 20/0.45 物镜(Zoom 6.3 × TV 2/3″″C)。使用的相机为 AxioCam MRc5,软件为 ZEN 3.2。横断面组织学图像以 2584 × 1936 像素的分辨率保存。在病例介绍部分或图例中,既未使用下游处理也未使用平均处理来提高图像的分辨率。

病例介绍

这是一例 67 岁男性患者的细菌性结膜炎罕见病例报告,该患者左眼白内障手术后五次切除后出现复发性结膜肉芽肿。我们进行了肿瘤切除术,并使用游离结膜自体移植。组织学显示包括巨噬细胞、粒细胞、淋巴细胞和反应性改变的鳞状细胞巢的纤维蛋白痂。这些发现与“细菌性结膜炎中的假性膜”一致。我们给予纤溶酶原激活剂、肝素、皮质类固醇和环孢素的局部联合治疗。

结论

纤溶酶原激活剂、肝素、皮质类固醇和环孢素的联合治疗已被证明可有效预防细菌性结膜炎的复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5e0/8897893/1b48f4386d8d/12886_2022_2329_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5e0/8897893/603671aeed60/12886_2022_2329_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5e0/8897893/fc0ec0a6ec90/12886_2022_2329_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5e0/8897893/1b48f4386d8d/12886_2022_2329_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5e0/8897893/603671aeed60/12886_2022_2329_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5e0/8897893/fc0ec0a6ec90/12886_2022_2329_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5e0/8897893/1b48f4386d8d/12886_2022_2329_Fig3_HTML.jpg

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2
An international registry of patients with plasminogen deficiency (HISTORY).国际纤维蛋白溶酶原缺乏症患者注册登记(HISTORY)。
Haematologica. 2020 Mar;105(3):554-561. doi: 10.3324/haematol.2019.241158. Epub 2020 Jan 30.
3
Prophylactic protocol for dental care in ligneous gingivitis due to severe plasminogen deficiency: Case report and review of literature.
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Haemophilia. 2019 Jul;25(4):693-698. doi: 10.1111/hae.13745. Epub 2019 Apr 17.
4
Plasminogen replacement therapy for the treatment of children and adults with congenital plasminogen deficiency.纤溶酶原替代疗法治疗先天性纤溶酶原缺乏症的儿童和成人。
Blood. 2018 Mar 22;131(12):1301-1310. doi: 10.1182/blood-2017-09-806729. Epub 2018 Jan 10.
5
Plasminogen deficiency.纤溶酶原缺乏症。
J Thromb Thrombolysis. 2017 Jan;43(1):132-138. doi: 10.1007/s11239-016-1416-6.
6
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8
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