Ulmer W
Strahlenther Onkol. 1986 Jun;162(6):374-86.
The linear-quadratic model provides, when applied to standard fractionation schemes, results comparable to the Ellis-formula, but it may also be applied to problems such as multifractionations, application of high single doses and afterloading methods (interstitial and intracavitary therapy with either short-time application or continuous irradiation), where the Ellis-formula is rather questionable. A further critical point of the latter formula is the estimation of late responses. However, the limitations of the linear-quadratic computation model may be determined by a comparison with a cubic survival formula S = exp (-(alpha D + beta D2 + delta D3] or with the Bender-Gooch-formula.
线性二次模型应用于标准分割方案时，其结果与埃利斯公式相当，但它也可用于多分割、高单次剂量应用以及后装治疗方法（短时间应用或连续照射的间质和腔内治疗）等问题，而埃利斯公式在这些问题上相当不可靠。后一个公式的另一个关键点是晚期反应的估计。然而，线性二次计算模型的局限性可以通过与三次生存公式S = exp (-(αD + βD² + δD³])或本德 - 古奇公式进行比较来确定。
