Hollander D M, Ebert E C, Roberts A I, Devereux D F
Surgery. 1986 Aug;100(2):292-7.
Cancer bearing is frequently accompanied by weight loss, yet the factors causing cancer cachexia remain unclear. This study compares how tumor type and tumor burden affect host carcass fat depletion. Nude mice were inoculated with human malignant melanoma, human colon adenocarcinoma, or murine sarcoma cells, or were noninjected controls. Body weights, tumor burdens, and carcass lipid contents were measured. Carcass weights of melanoma-bearing mice were significantly lower than those of sarcoma-bearing mice, mice exposed to colon cancer antigens but without tumor growth, or control mice (all p less than 0.02). The degree of carcass lipid loss in melanoma-bearing mice (mean tumor burden 3.5% of total body weight [TBW]) was almost three times that of sarcoma-bearing mice (p less than 0.05), which had more than twice the tumor burden (mean tumor burden 7.8% TBW). Exposure to colon cancer antigens without tumor growth resulted in essentially no carcass lipid depletion compared with control mice. These findings argue against a mass effect of tumor as being solely responsible for host fat mobilization and suggest that carcass lipid depletion in tumor-bearing nude mice is more a function of tumor type than of tumor burden.
患癌常常伴随着体重减轻，然而导致癌症恶病质的因素仍不清楚。本研究比较了肿瘤类型和肿瘤负荷如何影响宿主胴体脂肪消耗。将裸鼠接种人恶性黑色素瘤细胞、人结肠腺癌细胞或鼠肉瘤细胞，或作为未注射的对照。测量体重、肿瘤负荷和胴体脂质含量。携带黑色素瘤的小鼠的胴体重量显著低于携带肉瘤的小鼠、暴露于结肠癌抗原但无肿瘤生长的小鼠或对照小鼠（所有p均小于0.02）。携带黑色素瘤的小鼠（平均肿瘤负荷占总体重[TBW]的3.5%）的胴体脂质损失程度几乎是携带肉瘤的小鼠（p小于0.05）的三倍，而携带肉瘤的小鼠的肿瘤负荷是前者的两倍多（平均肿瘤负荷7.8%TBW）。与对照小鼠相比，暴露于结肠癌抗原但无肿瘤生长基本上不会导致胴体脂质消耗。这些发现表明肿瘤的质量效应并非是宿主脂肪动员的唯一原因，并提示携带肿瘤的裸鼠的胴体脂质消耗更多地是肿瘤类型的作用而非肿瘤负荷的作用。
