Edén E, Lindmark L, Karlberg I, Lundholm K
Cancer Res. 1983 Aug;43(8):3707-11.
This study was designed to ascertain whether the overall availability of whole-body lipids and nitrogen is a limiting factor for survival in tumor-bearing mice suffering from anorexia and cachexia. Three-month-old nongrowing mice (C57BL/6J) were given s.c. transplants of a methylcholanthrene-induced sarcoma. Freely fed, starved, and pair-fed animals were used. Body and lipid composition, tumor growth, and survival time were measured. Freely fed sarcoma-bearing mice died with profoundly altered body composition. This was not explained by the anorexia assessed in pair-feeding experiments. Starvation had caused a more severe depletion in body composition in both tumor-bearing and nontumor-bearing animals than the tumor alone did in freely fed tumor-bearing mice. Freely fed tumor-bearing animals had normal proportions of whole-body triglycerides, cholesterol, and polar lipids, but they lost palmitic acid quantitatively more than any other fatty acid. It is unlikely that any single fatty acid became limiting during tumor growth. The results show that the overall availability of lipids, nitrogen, and glucose precursors is not a limiting factor for survival in experimental tumor cachexia. Other factors considered to be more likely as determining factors for the death of tumor-bearing animals are discussed.
本研究旨在确定全身脂质和氮的总体可利用性是否是患有厌食症和恶病质的荷瘤小鼠生存的限制因素。对3个月大的非生长小鼠（C57BL/6J）进行皮下移植甲基胆蒽诱导的肉瘤。使用自由进食、饥饿和配对喂养的动物。测量身体和脂质组成、肿瘤生长和存活时间。自由进食的荷瘤小鼠死亡时身体组成发生了深刻变化。这无法用配对喂养实验中评估的厌食症来解释。饥饿导致荷瘤和未荷瘤动物的身体组成消耗比自由进食的荷瘤小鼠中肿瘤单独造成的消耗更严重。自由进食的荷瘤动物全身甘油三酯、胆固醇和极性脂质比例正常，但它们棕榈酸的定量损失比任何其他脂肪酸都多。在肿瘤生长过程中，任何单一脂肪酸都不太可能成为限制因素。结果表明，脂质、氮和葡萄糖前体的总体可利用性不是实验性肿瘤恶病质生存的限制因素。还讨论了其他被认为更可能是荷瘤动物死亡决定因素的因素。
