Yuspa S H, Viguera C, Nims R
Cancer Lett. 1979 Apr;6(4-5):301-10. doi: 10.1016/s0304-3835(79)80049-x.
The feasibility of utilizing neonatal human foreskins grafted to congenitally athymic nude mice for carcinogenesis studies was explored. Human grafts could be maintained morphologically intact for at least as long as 27 weeks. Topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) induced hyperplasia in human skin. Systemic administration of urethane followed by twice weekly topical TPA applications induced no mouse skin tumors in ungrafted nude mice and a moderate number in grafted nude mice. Two benign squamous papillary lesions developed in the human graft sites receiving TPA. One of these was likely of human origin but definitive origin of the second was uncertain.
探讨了利用移植到先天性无胸腺裸鼠身上的新生儿人类包皮进行致癌研究的可行性。人类移植物在形态上至少可以保持完整长达27周。局部应用12-O-十四烷酰佛波醇-13-乙酸酯（TPA）可诱导人类皮肤增生。在未移植裸鼠中，全身给予氨基甲酸乙酯，随后每周两次局部应用TPA，未诱导出小鼠皮肤肿瘤，而在移植裸鼠中诱导出了数量适中的肿瘤。在接受TPA的人类移植物部位出现了两个良性鳞状乳头状病变。其中一个可能起源于人类，但第二个的明确起源尚不确定。
