Gao Wenjing, Pan Tao, Fan Guangyuan, Cui Jian, Wang Tingting, Huang Nan, Jiang Changyou, Ma Lan, Wang Feifei, Liu Xing, Le Qiumin
The School of Basic Medical Sciences and Institutes of Brain Science, Fudan University, Shanghai, China.
Front Pharmacol. 2023 Jun 14;14:1211897. doi: 10.3389/fphar.2023.1211897. eCollection 2023.
A growing body of evidence suggests that parental substance abuse, even prior to conception, may induce phenotypic changes in offspring. Parental opioid exposure has been shown to affect developmental processes, induce memory deficits, and lead to psycho-emotional disorders in offspring. However, how parental, especially paternal, chronic drug exposure affects offspring remains unexplored. Adult male rats were subjected to 31 days of heroin self-administration followed by mating with naïve females. Litter size and body weight of F1 offspring were recorded. Object-based attention tests, cocaine self-administration tests, and hot plate tests were used to test for potential effects of chronic paternal heroin seeking on cognition, reward, or analgesic sensitivity in the offspring. Body weight and litter size of the heroin F1 generation were not altered compared to the saline F1 generation. Furthermore, paternal chronic heroin self-administration experience had no significant effect on object-based attention tests or cocaine self-administration behavior in either sex. However, in the hot plate test, although no difference in basal latency was found between the two groups in either sex, a significant increase in the analgesic effect of heroin was observed in the male heroin F1 generation. Taken together, these data provide evidence that paternal chronic heroin self-administration experience could sex-dimorphically increase the analgesic effect of heroin in male offspring, but had no significant effect on response to cocaine reinforcement or attentional behavior.
越来越多的证据表明，即使在受孕前，父母的药物滥用也可能导致后代的表型变化。已有研究表明，父母接触阿片类药物会影响发育过程、导致记忆缺陷，并使后代出现心理情绪障碍。然而，父母尤其是父亲长期药物接触如何影响后代仍未得到探索。成年雄性大鼠接受31天的海洛因自我给药，然后与未接触过海洛因的雌性大鼠交配。记录F1代后代的窝仔数和体重。使用基于物体的注意力测试、可卡因自我给药测试和热板测试来检测父亲长期寻求海洛因对后代认知、奖赏或镇痛敏感性的潜在影响。与生理盐水F1代相比，海洛因F1代的体重和窝仔数没有改变。此外，父亲长期海洛因自我给药经历对两性基于物体的注意力测试或可卡因自我给药行为均无显著影响。然而，在热板测试中，虽然两组两性的基础潜伏期均无差异，但在雄性海洛因F1代中观察到海洛因镇痛效果显著增加。综上所述，这些数据表明，父亲长期海洛因自我给药经历可能会以性别差异的方式增加雄性后代对海洛因的镇痛效果，但对可卡因强化反应或注意力行为没有显著影响。
