游离甲状腺素测定用于成年人群甲状腺功能亢进和减退的筛查。

Free thyroxine estimation for the screening of hyper- and hypothyroidism in an adult population.

作者信息

Fukazawa H, Sakurada T, Yoshida K, Kitaoka H, Nomura T, Suzuki M, Kaise N, Kaise K, Yamamoto M, Saito S

出版信息

Tohoku J Exp Med. 1986 Apr;148(4):411-20. doi: 10.1620/tjem.148.411.

DOI:10.1620/tjem.148.411

Abstract

Serum free thyroxine (FT4), total T4 (T4) and total T3 (T3) were determined by radioimmunoassay in 1,114 adults during a periodic health evaluation to detect unsuspected thyroid dysfunction. As a result, 3 patients with hyperthyroidism, 4 with hypothyroidism, 3 taking thyroid medication, 4 with chronic thyroiditis, 1 with simple goiter and 3 women under estrogen administration were found. Free T4 values were within the normal limits in the present four subjects taking estrogens, but all of them showed high T4 and one high T3 values. FT4 and T4 were low in four patients with hypothyroidism, but two of them showed normal T3 values. For the screening of hyperthyroidism, FT4 was the most reliable measurement and determination of either FT4 or T4 was suitable for the screening of hypothyroidism, but T3 measurement did not diagnose all patients with hypothyroidism, but T3 measurement did not diagnose all patients with hypothyroidism.

摘要

在一项定期健康评估中，通过放射免疫分析法对1114名成年人测定了血清游离甲状腺素（FT4）、总甲状腺素（T4）和总三碘甲状腺原氨酸（T3），以检测未被怀疑的甲状腺功能障碍。结果发现，有3例甲状腺功能亢进患者、4例甲状腺功能减退患者、3例正在服用甲状腺药物的患者、4例慢性甲状腺炎患者、1例单纯性甲状腺肿患者以及3例正在接受雌激素治疗的女性。在目前这4例接受雌激素治疗的受试者中，游离T4值在正常范围内，但他们所有人的T4值都偏高，且有1例T3值偏高。4例甲状腺功能减退患者的FT4和T4值较低，但其中2例的T3值正常。对于甲状腺功能亢进的筛查，FT4是最可靠的测量指标，测定FT4或T4均适用于甲状腺功能减退的筛查，但T3测量不能诊断所有甲状腺功能减退患者。